The natural-like spiroketal, 2-hydroxy-8-methyl-1,7-dioxaspiro[5.5]undec-3-en-5-one (1) has been synthesised and has shown a potent antitumor activity against human tumor cells of different nature and histotype. We have now performed studies for verify its in vivo activity on a murine melanoma model and in vitro studies to shed some light on the mechanism of action.
A New synthetic spiroketal: Antitumor Activity On Murine Melanoma Model In Vivo and MOA In Vitro
Pietro Spanu;Maria Pia Fuggetta;Fausta Ulgheri;Giovanni Loriga;Paola Carta;Adriano Barra;
2018
Abstract
The natural-like spiroketal, 2-hydroxy-8-methyl-1,7-dioxaspiro[5.5]undec-3-en-5-one (1) has been synthesised and has shown a potent antitumor activity against human tumor cells of different nature and histotype. We have now performed studies for verify its in vivo activity on a murine melanoma model and in vitro studies to shed some light on the mechanism of action.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.