SAVINO, CARMELINDA
SAVINO, CARMELINDA
Istituto di Biologia e Patologia Molecolari - IBPM
Novel Humanized Anti-HER3 Antibodies: Structural Characterization and Therapeutic Activity
2025 Muzi, Alessia; Arriga, Roberto; Bulfaro, Giovanni; Fata, Francesca; Costanzo, Antonella; Chiarini, Valerio; Cappelletti, Manuela; Fosca Ferrara, Fabiana; Bucci, Federica; Montemiglio, Linda Celeste; Savino, Carmelinda; Marra, Emanuele; Ciliberto, Gennaro; Aurisicchio, Luigi; Vallone, Beatrice; Roscilli, Giuseppe
Binding of steroid substrates reveals the key to the productive transition of the cytochrome P450 OleP
2024 Costanzo, Antonella; Fata, Francesca; Freda, Ida; De Sciscio, Maria Laura; Gugole, Elena; Bulfaro, Giovanni; Di Renzo, Matteo; Barbizzi, Luca; Exertier, Cécile; Parisi, Giacomo; D'Abramo, Marco; Vallone, Beatrice; Savino, Carmelinda; Montemiglio, Linda Celeste
Effect of salts on the conformational dynamics of the cytochrome P450 OleP
2023 De Sciscio, M L; Nardi, A N; Parisi, G; Bulfaro, G; Costanzo, A; Gugole, E; Exertier, C; Freda, I; Savino, C; Vallone, B; Montemiglio, LINDA CELESTE; D'Abramo, M
Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR
2023 Freda, I; Exertier, C; Barile, A; Chavessanjuan, A; Vega, Mv; Isupov, Mn; Harmer, Nj; Gugole, E; Swuec, P; Bolognesi, M; Scipioni, A; Savino, C; Di Salvo, Ml; Contestabile, R; Vallone, B; Tramonti, A; Montemiglio, Lc
Neuroglobin, clues to function and mechanism
2022 Exertier, C; Montemiglio, Lc; Freda, I; Gugole, E; Parisi, G; Savino, C; Vallone, B
Point mutations at a key site alter the cytochrome P450 oleP structural dynamics
2022 Montemiglio, Lc; Gugole, E; Freda, I; Exertier, C; D'Auria, L; Chen, Cg; Nardi, An; Cerutti, G; Parisi, G; D'Abramo, M; Savino, C; Vallone, B
Probing the role of the murine neuroglobin CDloop-D-helix unit in CO ligand binding and structural dynamics.
2022 Exertier, C.; Sebastiani, F.; Freda, I.; Gugole, E.; Cerutti, G.; Parisi, G.; Montemiglio, L. C.; Becucci, M.; Zamparelli, C.; Viappiani, C.; Bruno, S.; Savino, C.; Anselmi, M.; Abbruzzetti, S.; Smulevich, G.; Vallone, B.
Crystal structure and functional characterization of an oligosaccharide dehydrogenase from Pycnoporus cinnabarinus provides insights into fungal breakdown of lignocellulose
2021 Cerutti, G; Gugole, E; Montemiglio, Lc; Turbedoan, A; Chena, D; Navarro, D; Lomascolo, A; Piumi, F; Exertier, C; Freda, I; Vallone, B; Record, E; Savino, C; Sciara, G
Biodistribution PET/CT study of hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice
2020 Kiraga, L.; Cerutti, G.; Braniewska, A.; Strzemecki, D.; Sas, Z.; Boffi, A.; Savino, C.; Montemiglio, L. C.; Turnham, D.; Seaton, G.; Bonamore, A.; Clarkson, R.; Dabkowski, A.; Paisey, S. J.; Taciak, B.; Kucharzewska, P.; Rygiel, T. P.; Król, M
Dissecting the cytochrome p450 olep substrate specificity: Evidence for a preferential substrate
2020 Parisi, G; Freda, I; Exertier, C; Cecchetti, C; Gugole, E; Cerutti, G; D'Auria, L; Macone, A; Vallone, B; Savino, C; Montemiglio, Lc
Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy
2020 Milazzo, Lisa; Exertier, Cecile; Becucci, Maurizio; Freda, Ida; Montemiglio, LINDA CELESTE; Savino, Carmelinda; Vallone, Beatrice; Smulevich, Giulietta
Cryo-EM structure of the human ferritin-transferrin receptor 1 complex
2019 Montemiglio, LINDA CELESTE; Testi, Claudia; Ceci, Pierpaolo; Falvo, Elisabetta; Pitea, Martina; Savino, Carmelinda; Arcovito, Alessandro; Peruzzi, Giovanna; Baiocco, Paola; Mancia, Filippo; Boffi, Alberto; des Georges, Amedee; Vallone, Beatrice
Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments
2019 Ardiccioni, Chiara; Arcovito, Alessandro; Della Longa, Stefano; van der Linden, Peter; Bourgeois, Dominique; Weik, Martin; Montemiglio, Linda Celeste; Savino, Carmelinda; Avella, Giovanna; Exertier, Cecile; Carpentier, Philippe; Prange, Thierry; Brunori, Maurizio; Colloc'h, Nathalie; Vallone, Beatrice
Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating
2019 Exertier, Cecile; Milazzo, Lisa; Freda, Ida; Montemiglio, LINDA CELESTE; Scaglione, Antonella; Cerutti, Gabriele; Parisi, Giacomo; Anselmi, Massimiliano; Smulevich, Giulietta; Savino, Carmelinda; Vallone, Beatrice
Substrate-induced conformational change in cytochrome P450 OleP
2019 Parisi, Giacomo; Montemiglio, Linda Celeste; Giuffrè, Alessandro; Macone, Alberto; Scaglione, Antonella; Cerutti, Gabriele; Exertier, Cécile; Savino, Carmelinda; Vallone, Beatrice;
Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain
2018 Scaglione, Antonella; Monteonofrio, Laura; Parisi, Giacomo; Cecchetti, Cristina; Siepi, Francesca; Rinaldo, Cinzia; Giorgi, Alessandra; Verzili, Daniela; Zamparelli, Carlotta; Savino, Carmelinda; Soddu, Silvia; Vallone, Beatrice; Montemiglio, LINDA CELESTE
Structure of the adenylation domain Thr1 involved in the biosynthesis of 4-chlorothreonine in Streptomyces sp. OH-5093-protein flexibility and molecular bases of substrate specificity
2017 Scaglione, Antonella; Scaglione, Antonella; Fullone, Maria Rosaria; Montemiglio, Linda Celeste; Montemiglio, Linda Celeste; Parisi, Giacomo; Parisi, Giacomo; Zamparelli, Carlotta; Vallone, Beatrice; Vallone, Beatrice; Savino, Carmelinda; Grgurina, Ingeborg
Subcellular localization of the five members of the human steroid 5?-reductase family
2017 Scaglione, A; Montemiglio, Lc; Parisi, G; Asteriti, Ia; Bruni, R; Cerutti, G; Testi, C; Savino, C; Mancia, F; Lavia, P; Vallone, B
Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis
2016 Montemiglio, LINDA CELESTE; Parisi, Giacomo; Scaglione, Antonella; Sciara, Giuliano; Savino, Carmelinda; Vallone, Beatrice
Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism
2014 Avella, G.; Ardiccioni, C.; Scaglione, A.; Moschetti, T.; Rondinelli, C.; Montemiglio, L. C.; Savino, C.; Giuffre, A.; Brunori, M.; Vallone, Beatrice
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Novel Humanized Anti-HER3 Antibodies: Structural Characterization and Therapeutic Activity | 1-gen-2025 | Muzi, Alessia; Arriga, Roberto; Bulfaro, Giovanni; Fata, Francesca; Costanzo, Antonella; Chiarini, Valerio; Cappelletti, Manuela; Fosca Ferrara, Fabiana; Bucci, Federica; Montemiglio, Linda Celeste; Savino, Carmelinda; Marra, Emanuele; Ciliberto, Gennaro; Aurisicchio, Luigi; Vallone, Beatrice; Roscilli, Giuseppe | |
| Binding of steroid substrates reveals the key to the productive transition of the cytochrome P450 OleP | 1-gen-2024 | Costanzo, Antonella; Fata, Francesca; Freda, Ida; De Sciscio, Maria Laura; Gugole, Elena; Bulfaro, Giovanni; Di Renzo, Matteo; Barbizzi, Luca; Exertier, Cécile; Parisi, Giacomo; D'Abramo, Marco; Vallone, Beatrice; Savino, Carmelinda; Montemiglio, Linda Celeste | |
| Effect of salts on the conformational dynamics of the cytochrome P450 OleP | 1-gen-2023 | De Sciscio, M L; Nardi, A N; Parisi, G; Bulfaro, G; Costanzo, A; Gugole, E; Exertier, C; Freda, I; Savino, C; Vallone, B; Montemiglio, LINDA CELESTE; D'Abramo, M | |
| Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR | 1-gen-2023 | Freda, I; Exertier, C; Barile, A; Chavessanjuan, A; Vega, Mv; Isupov, Mn; Harmer, Nj; Gugole, E; Swuec, P; Bolognesi, M; Scipioni, A; Savino, C; Di Salvo, Ml; Contestabile, R; Vallone, B; Tramonti, A; Montemiglio, Lc | |
| Neuroglobin, clues to function and mechanism | 1-gen-2022 | Exertier, C; Montemiglio, Lc; Freda, I; Gugole, E; Parisi, G; Savino, C; Vallone, B | |
| Point mutations at a key site alter the cytochrome P450 oleP structural dynamics | 1-gen-2022 | Montemiglio, Lc; Gugole, E; Freda, I; Exertier, C; D'Auria, L; Chen, Cg; Nardi, An; Cerutti, G; Parisi, G; D'Abramo, M; Savino, C; Vallone, B | |
| Probing the role of the murine neuroglobin CDloop-D-helix unit in CO ligand binding and structural dynamics. | 1-gen-2022 | Exertier, C.; Sebastiani, F.; Freda, I.; Gugole, E.; Cerutti, G.; Parisi, G.; Montemiglio, L. C.; Becucci, M.; Zamparelli, C.; Viappiani, C.; Bruno, S.; Savino, C.; Anselmi, M.; Abbruzzetti, S.; Smulevich, G.; Vallone, B. | |
| Crystal structure and functional characterization of an oligosaccharide dehydrogenase from Pycnoporus cinnabarinus provides insights into fungal breakdown of lignocellulose | 1-gen-2021 | Cerutti, G; Gugole, E; Montemiglio, Lc; Turbedoan, A; Chena, D; Navarro, D; Lomascolo, A; Piumi, F; Exertier, C; Freda, I; Vallone, B; Record, E; Savino, C; Sciara, G | |
| Biodistribution PET/CT study of hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice | 1-gen-2020 | Kiraga, L.; Cerutti, G.; Braniewska, A.; Strzemecki, D.; Sas, Z.; Boffi, A.; Savino, C.; Montemiglio, L. C.; Turnham, D.; Seaton, G.; Bonamore, A.; Clarkson, R.; Dabkowski, A.; Paisey, S. J.; Taciak, B.; Kucharzewska, P.; Rygiel, T. P.; Król, M | |
| Dissecting the cytochrome p450 olep substrate specificity: Evidence for a preferential substrate | 1-gen-2020 | Parisi, G; Freda, I; Exertier, C; Cecchetti, C; Gugole, E; Cerutti, G; D'Auria, L; Macone, A; Vallone, B; Savino, C; Montemiglio, Lc | |
| Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy | 1-gen-2020 | Milazzo, Lisa; Exertier, Cecile; Becucci, Maurizio; Freda, Ida; Montemiglio, LINDA CELESTE; Savino, Carmelinda; Vallone, Beatrice; Smulevich, Giulietta | |
| Cryo-EM structure of the human ferritin-transferrin receptor 1 complex | 1-gen-2019 | Montemiglio, LINDA CELESTE; Testi, Claudia; Ceci, Pierpaolo; Falvo, Elisabetta; Pitea, Martina; Savino, Carmelinda; Arcovito, Alessandro; Peruzzi, Giovanna; Baiocco, Paola; Mancia, Filippo; Boffi, Alberto; des Georges, Amedee; Vallone, Beatrice | |
| Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments | 1-gen-2019 | Ardiccioni, Chiara; Arcovito, Alessandro; Della Longa, Stefano; van der Linden, Peter; Bourgeois, Dominique; Weik, Martin; Montemiglio, Linda Celeste; Savino, Carmelinda; Avella, Giovanna; Exertier, Cecile; Carpentier, Philippe; Prange, Thierry; Brunori, Maurizio; Colloc'h, Nathalie; Vallone, Beatrice | |
| Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating | 1-gen-2019 | Exertier, Cecile; Milazzo, Lisa; Freda, Ida; Montemiglio, LINDA CELESTE; Scaglione, Antonella; Cerutti, Gabriele; Parisi, Giacomo; Anselmi, Massimiliano; Smulevich, Giulietta; Savino, Carmelinda; Vallone, Beatrice | |
| Substrate-induced conformational change in cytochrome P450 OleP | 1-gen-2019 | Parisi, Giacomo; Montemiglio, Linda Celeste; Giuffrè, Alessandro; Macone, Alberto; Scaglione, Antonella; Cerutti, Gabriele; Exertier, Cécile; Savino, Carmelinda; Vallone, Beatrice; | |
| Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain | 1-gen-2018 | Scaglione, Antonella; Monteonofrio, Laura; Parisi, Giacomo; Cecchetti, Cristina; Siepi, Francesca; Rinaldo, Cinzia; Giorgi, Alessandra; Verzili, Daniela; Zamparelli, Carlotta; Savino, Carmelinda; Soddu, Silvia; Vallone, Beatrice; Montemiglio, LINDA CELESTE | |
| Structure of the adenylation domain Thr1 involved in the biosynthesis of 4-chlorothreonine in Streptomyces sp. OH-5093-protein flexibility and molecular bases of substrate specificity | 1-gen-2017 | Scaglione, Antonella; Scaglione, Antonella; Fullone, Maria Rosaria; Montemiglio, Linda Celeste; Montemiglio, Linda Celeste; Parisi, Giacomo; Parisi, Giacomo; Zamparelli, Carlotta; Vallone, Beatrice; Vallone, Beatrice; Savino, Carmelinda; Grgurina, Ingeborg | |
| Subcellular localization of the five members of the human steroid 5?-reductase family | 1-gen-2017 | Scaglione, A; Montemiglio, Lc; Parisi, G; Asteriti, Ia; Bruni, R; Cerutti, G; Testi, C; Savino, C; Mancia, F; Lavia, P; Vallone, B | |
| Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis | 1-gen-2016 | Montemiglio, LINDA CELESTE; Parisi, Giacomo; Scaglione, Antonella; Sciara, Giuliano; Savino, Carmelinda; Vallone, Beatrice | |
| Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism | 1-gen-2014 | Avella, G.; Ardiccioni, C.; Scaglione, A.; Moschetti, T.; Rondinelli, C.; Montemiglio, L. C.; Savino, C.; Giuffre, A.; Brunori, M.; Vallone, Beatrice |