Appetite for copper: Ubiquitin is a hallmark of toxic aggregates in neurodegenerative disorders, where metal ions are believed to play a crucial role. Copper(II) ions have been found to bind to ubiquitin at a specific site involving the N-terminal nitrogen of Met1 and three oxygen donor ligands in a tetragonal geometry. The affinity of this site for copper(II) is comparable to that of other amyloidogenic proteins involved in neurodegenerative disorders.
Ubiquitin stability and the lys 63-linked polyubiquitination site are compromised on copper binding.
Danilo Milardi;Giulia Grasso;Enrico Rizzarelli
2007
Abstract
Appetite for copper: Ubiquitin is a hallmark of toxic aggregates in neurodegenerative disorders, where metal ions are believed to play a crucial role. Copper(II) ions have been found to bind to ubiquitin at a specific site involving the N-terminal nitrogen of Met1 and three oxygen donor ligands in a tetragonal geometry. The affinity of this site for copper(II) is comparable to that of other amyloidogenic proteins involved in neurodegenerative disorders.File in questo prodotto:
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