Here, we present the method that we have established for the simultaneous typing of the APOE and TF genes based on the ligation detection reaction (LDR)/universal array approach. The apolipoprotein E locus (APOE) is a known major susceptibility factor of AD disease. Among additional genetic loci associated with disease development, the transferrin gene (TF) has been suggested as a candidate locus for AD because it is the major transport protein for iron, which itself is an important factor in free-radical generation.
Apolipoprotein E and transferrin genotyping by ligation detection reaction and universal array
Bordoni R;Castiglioni B;Mezzelani A;Rizzi E;Consolandi C;De Bellis G
2003
Abstract
Here, we present the method that we have established for the simultaneous typing of the APOE and TF genes based on the ligation detection reaction (LDR)/universal array approach. The apolipoprotein E locus (APOE) is a known major susceptibility factor of AD disease. Among additional genetic loci associated with disease development, the transferrin gene (TF) has been suggested as a candidate locus for AD because it is the major transport protein for iron, which itself is an important factor in free-radical generation.File in questo prodotto:
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