A new route for the synthesis of isofagomine analogues has been carried out by using as precursors enan- tiopure 5-trihydroxypropyl-dihydrouracil derivatives obtained from aldol-type addition of 1,3-dibenzyl- dihydrouracil to isopropylidene-protected glyceraldehyde. The synthesis of D-galacto-isofagomine is reported.
5-Trihydroxypropyl-dihydrouracil derivatives as precursors of 1-azasugars: application to the stereoselective synthesis of D-galacto-isofagomine
Pietro Spanu;Fausta Ulgheri
2010
Abstract
A new route for the synthesis of isofagomine analogues has been carried out by using as precursors enan- tiopure 5-trihydroxypropyl-dihydrouracil derivatives obtained from aldol-type addition of 1,3-dibenzyl- dihydrouracil to isopropylidene-protected glyceraldehyde. The synthesis of D-galacto-isofagomine is reported.File in questo prodotto:
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