O2, NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O2 respiration, denitrification, N2 fixation, and methanogenesis. Over the last decade, O2, NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.
CO Sniffing through Heme-based Sensor Proteins
Milani M;
2004
Abstract
O2, NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O2 respiration, denitrification, N2 fixation, and methanogenesis. Over the last decade, O2, NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
