The synthesis of 5-(alditol-1-C-yl)-hydantoin derivatives was performed via diastereoselective aldol-type addition of 1,3-dibenzyl-hydantoin to enantiopure aldehydo Sugars. Starting from the D-ribo-configured 5-(alditol-1-C-yl)-hydantoin template, the synthesis of (2R,3S,4R)-3,4,5-trihydroxynorvaline was carried out.
Diastereoselective synthesis of 5-(alditol-1-C-yl)-hydantoins and their use as precursors of polyhydroxylated alpha-amino acids
F Ulgheri;M Crisma;P Spanu
2004
Abstract
The synthesis of 5-(alditol-1-C-yl)-hydantoin derivatives was performed via diastereoselective aldol-type addition of 1,3-dibenzyl-hydantoin to enantiopure aldehydo Sugars. Starting from the D-ribo-configured 5-(alditol-1-C-yl)-hydantoin template, the synthesis of (2R,3S,4R)-3,4,5-trihydroxynorvaline was carried out.File in questo prodotto:
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