Laser-driven electron accelerators based on the Laser Wakefield Acceleration process has entered a mature phase to be considered as alternative devices to conventional radiofrequency linear accelerators used in medical applications. Before entering the medical practice, however, deep studies of the radiobiological effects of such short bunches as the ones produced by laser-driven accelerators have to be performed. Here we report on the setup, characterization and first test of a small-scale laser accelerator for radiobiology experiments. A brief description of the experimental setup will be given at first, followed by an overview of the electron bunch characterization, in particular in terms of dose delivered to the samples. Finally, the first results from the irradiation of biological samples will be briefly discussed.

Small-scale laser based electron accelerators for biology and medicine: a comparative study of the biological effectiveness

Labate;Luca;Andreassi;Baffigi;Federica;Basta;Giuseppina;Bizzarri;Ranieri;Andrea;Fulgentini;Lorenzo;Ghetti;Francesco;Gilardi;Maria Carla;Giulietti;Antonio;Petra;Lenci;Francesco;Levato;Tadzio;Russo;Giorgio;Sgarbossa;Antonella;Gizzi;Leonida A
2013

Abstract

Laser-driven electron accelerators based on the Laser Wakefield Acceleration process has entered a mature phase to be considered as alternative devices to conventional radiofrequency linear accelerators used in medical applications. Before entering the medical practice, however, deep studies of the radiobiological effects of such short bunches as the ones produced by laser-driven accelerators have to be performed. Here we report on the setup, characterization and first test of a small-scale laser accelerator for radiobiology experiments. A brief description of the experimental setup will be given at first, followed by an overview of the electron bunch characterization, in particular in terms of dose delivered to the samples. Finally, the first results from the irradiation of biological samples will be briefly discussed.
2013
Istituto di Biofisica - IBF
Istituto di Bioimmagini e Fisiologia Molecolare - IBFM
Istituto di Fisiologia Clinica - IFC
Istituto Nazionale di Ottica - INO
Inglese
Eric Esarey; Carl B. Schroeder; Wim P. Leemans; Dino A. Jaroszynski; Kenneth W. D. Ledingham
LASER ACCELERATION OF ELECTRONS, PROTONS, AND IONS II; AND MEDICAL APPLICATIONS OF LASER-GENERATED BEAMS OF PARTICLES II; AND HARNESSING RELATIVISTIC PLASMA WAVES III
Conference on Laser Acceleration of Electrons, Protons, and Ions II; and Medical Applications of Laser-Generated Beams of Particles II; and Harnessing Relativistic Plasma Waves III
8779
87790O
87790O
7
978-0-8194-9581-5
http://dx.doi.org/10.1117/12.2019689
SPIE-INT SOC OPTICAL ENGINEERING
BELLINGHAM, WA 98227-0010
STATI UNITI D'AMERICA
Sì, ma tipo non specificato
APR 15-18, 2013
Prague, CZECH REPUBLIC
44
none
Labate, LUCA UMBERTO; Labate, LUCA UMBERTO; Andreassi, Mariagrazia; Maria, Grazia; Baffigi, Federica; Baffigi, Federica; Basta, Giuseppina; Basta, Giu...espandi
273
info:eu-repo/semantics/conferenceObject
04 Contributo in convegno::04.01 Contributo in Atti di convegno
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/19196
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