Synthesis of a-6-sulfoquinovosyl-1,2-O-diacylglycerols is achieved by a versatile chemo-enzymatic stereoselective procedure that involves the use of a-D-glucosidase activity from the Mediterranean mollusc Aplysia fasciata. The synthetic procedure is designed to obtain a wide diversity of regio- and stereo-isomers of these compounds that have gained great interest as antineoplastic agents and potent inhibitors of DNA polymerases.
Chemoenzymatic preparation of alfa-6-sulfoquinovosyl-1,2-O-diacylglycerols
Emiliano Manzo;Annabella Tramice;Antonio Trincone;Angelo Fontana
2012
Abstract
Synthesis of a-6-sulfoquinovosyl-1,2-O-diacylglycerols is achieved by a versatile chemo-enzymatic stereoselective procedure that involves the use of a-D-glucosidase activity from the Mediterranean mollusc Aplysia fasciata. The synthetic procedure is designed to obtain a wide diversity of regio- and stereo-isomers of these compounds that have gained great interest as antineoplastic agents and potent inhibitors of DNA polymerases.File in questo prodotto:
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