Abstract: RNA interference and transgene-mediated cosuppression are trans-generational silencing mechanisms acting both at a post-transcriptional and epigenetic level. We have recently shown that both these procedures, which share several common factors and are commonly used to phenocopy gene deletions, also induce germ-line DNA damage and apoptosis. These observations shed new light on the cross-talk between different pathways devoted to the protection of genome stability in germ cells.
Try to disarm the intruder or kill him!
Adamo A;La Volpe A
2012
Abstract
Abstract: RNA interference and transgene-mediated cosuppression are trans-generational silencing mechanisms acting both at a post-transcriptional and epigenetic level. We have recently shown that both these procedures, which share several common factors and are commonly used to phenocopy gene deletions, also induce germ-line DNA damage and apoptosis. These observations shed new light on the cross-talk between different pathways devoted to the protection of genome stability in germ cells.File in questo prodotto:
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