Acetyl chloride reacts with pyridine to give a mixture of N-acetyl-1,4- and 1,2-dihydropyridyl acetic acid after water quenching . The reaction involves the formation of a zwitterionic ketene enolate intermediate which results from deprotonation of the acetyl moiety of the in situ formed N-acetyl pyridinium ion.
Synthesis of dihydropyridine and piperidine derivatives via an unexpected reaction of pyridine with acetyl chloride
P Spanu;F Ulgheri
2013
Abstract
Acetyl chloride reacts with pyridine to give a mixture of N-acetyl-1,4- and 1,2-dihydropyridyl acetic acid after water quenching . The reaction involves the formation of a zwitterionic ketene enolate intermediate which results from deprotonation of the acetyl moiety of the in situ formed N-acetyl pyridinium ion.File in questo prodotto:
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