D-Galactose/D-glucose-binding protein from E. coli (GGBP) is a monomer that binds glucose with high affinity. The protein structure of GGBP is organized in two principal domains linked by a hinge region that form the sugar-binding site. In this work we show that the mutant form of GGBP at the amino acid position 182 can be utilized as a probe for the development of a non-consuming analyte fluorescence biosensor to monitor the glucose level in diabetes health care. © 2007 by MDPI.
D-galactose/D-glucose-binding protein from escherichia coli as probe for a non-consuming glucose implantable fluorescence biosensor
Aurilia Vincenzo;Staiano Maria;Ruggiero Giuseppe;Orlando Pierangelo;Labella Tullio;D'Auria Sabato
2007
Abstract
D-Galactose/D-glucose-binding protein from E. coli (GGBP) is a monomer that binds glucose with high affinity. The protein structure of GGBP is organized in two principal domains linked by a hinge region that form the sugar-binding site. In this work we show that the mutant form of GGBP at the amino acid position 182 can be utilized as a probe for the development of a non-consuming analyte fluorescence biosensor to monitor the glucose level in diabetes health care. © 2007 by MDPI.File in questo prodotto:
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