A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site. This journal is
Out of the active site binding pocket for carbonic anhydrase inhibitors
D'Ambrosio K;Monti SM;Buonanno M;De Simone G
2015
Abstract
A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site. This journal isFile in questo prodotto:
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Descrizione: Out of the active site binding pocket for carbonic anhydrase inhibitors
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