CNR Institutional Research Information System

A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site. This journal is

Out of the active site binding pocket for carbonic anhydrase inhibitors

D'Ambrosio K;Monti SM;Buonanno M;De Simone G
2015

Abstract

A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site. This journal is
2015
Istituto di Biostrutture e Bioimmagini - IBB - Sede Napoli
Inglese
51
2
302
305
4
2-s2.0-84916227702
http://www.scopus.com/inward/record.url?eid=2-s2.0-84916227702&partnerID=q2rCbXpz
Esperti anonimi
Sì
Carbonic anhydrase
drug design
inhibitors
Internazionale
Elettronico
8
info:eu-repo/semantics/article
262
D'Ambrosio, K; Carradori, S; Monti, Sm; Buonanno, M; Secci, D; Vullo, D; Supuran, Ct; De Simone, G
01 Contributo su Rivista::01.01 Articolo in rivista
open
01.01 Articolo in rivista
File in questo prodotto:
File Dimensione Formato  
prod_298789-doc_163363.pdf

accesso aperto

Descrizione: Out of the active site binding pocket for carbonic anhydrase inhibitors
Tipologia: Documento in Post-print
Licenza: Creative commons
Dimensione 836.03 kB
Formato Adobe PDF
Visualizza/Apri
836.03 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/286593
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 124
  • ???jsp.display-item.citation.isi??? ND
social impact