In this paper, we study the rigorous sharp interface limit of a diffuse interface model related to the dynamics of tumor growth, when a parameter (Formula presented.), representing the interface thickness between the tumorous and non-tumorous cells, tends to zero. More in particular, we analyze here a gradient-flow-type model arising from a modification of the recently introduced model for tumor growth dynamics in Hawkins-Daruud et al. (Int J Numer Math Biomed Eng 28:3-24, 2011) (cf. also Hilhorst et al. Math Models Methods Appl Sci 25:1011-1043, 2015). Exploiting the techniques related to both gradient flows and gamma convergence, we recover a condition on the interface (Formula presented.) relating the chemical and double-well potentials, the mean curvature, and the normal velocity.

A rigorous sharp interface limit of a diffuse interface model related to tumor growth

E Rocca;
2017

Abstract

In this paper, we study the rigorous sharp interface limit of a diffuse interface model related to the dynamics of tumor growth, when a parameter (Formula presented.), representing the interface thickness between the tumorous and non-tumorous cells, tends to zero. More in particular, we analyze here a gradient-flow-type model arising from a modification of the recently introduced model for tumor growth dynamics in Hawkins-Daruud et al. (Int J Numer Math Biomed Eng 28:3-24, 2011) (cf. also Hilhorst et al. Math Models Methods Appl Sci 25:1011-1043, 2015). Exploiting the techniques related to both gradient flows and gamma convergence, we recover a condition on the interface (Formula presented.) relating the chemical and double-well potentials, the mean curvature, and the normal velocity.
2017
Istituto di Matematica Applicata e Tecnologie Informatiche - IMATI -
Cahn-Hilliard equation
Diffuse interface models
Gamma convergence
Gradient-flow
Nonlocal operators
Reaction-diffusion equation
Sharp interface limit
Tumor growth
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/329089
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