Non-alcoholic fatty liver disease (NAFLD) has a bidirectional relationship with insulin resistance (IR): the liver isthe target of an increased flux of Free Fatty Acids (FFAs) and adipokines stemming from a dysfunctional adipose tissue (AT) but a fatty liver actively contributesto the dyslipidemic profile and to the chronic low grade inflammation. Soluble CD163 (sCD163), a marker of hepatic macrophages activation, has been associated with fibrosis in NAFLD. Our aim is to elucidate the link between IR in the liver and in the AT, hepatic macrophages activation and liver damage in 40 non-diabetic patients with NAFLD
Hepatic macrophage activation is associated with adipose tissue insulin resistance in non-diabetic patients with Non-Alcoholic Fatty Liver Disease
Gaggini Melania;Buzzigoli Emma;Gastaldelli Amalia;
2016
Abstract
Non-alcoholic fatty liver disease (NAFLD) has a bidirectional relationship with insulin resistance (IR): the liver isthe target of an increased flux of Free Fatty Acids (FFAs) and adipokines stemming from a dysfunctional adipose tissue (AT) but a fatty liver actively contributesto the dyslipidemic profile and to the chronic low grade inflammation. Soluble CD163 (sCD163), a marker of hepatic macrophages activation, has been associated with fibrosis in NAFLD. Our aim is to elucidate the link between IR in the liver and in the AT, hepatic macrophages activation and liver damage in 40 non-diabetic patients with NAFLDFile in questo prodotto:
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