Gender effect on phenotype and genotype in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis: results from the MYSEC project

In this study, we assessed the prognostic impact of gender in the study population of the multicenter MYSEC project including 684 SMF patients with driver mutational status available. Diagnosis of SMF was performed between 1981 and 2015 and were locally reviewed according to the International Working Group on Myeloproliferative Neoplasm Research and Treatment criteria (IWG-MRT 2008)1. Molecular and genetic tests were performed as previously described9,10. The study was approved by the ethical committee of each institution and conducted in accordance with the Declaration of Helsinki. Statistical analyses considered clinical and laboratory data collected at the time of progression to SMF. Wilcoxon rank sum and Pearson’s chi-squared tests were performed to report differences between the groups, whereas Kaplan–Meier estimators, log-rank tests, and Cox regression models were used for time-to-event analysis.