The olive leaves represent a rich source of biophenols with pharmaceutical and nutraceutical activities. This biomass is a renewable material from which important phytotherapics such as oleuropein, rutin and verbascoside can be extracted. The development of environmentally friendly strategies for the valorization of biomass is of crucial importance in view of a circular economy. In this work, the bioconversion of oleuropein to produce oleuropein aglycone (OA) and its encapsulation in particles was investigated by an integrated membrane process. The biocatalytic membrane reactor (BMR) has been studied for the production of oleuropein aglycone using oleuropein contained in olive leaves extract [1]. Subsequently, oleuropein aglycone was encapsulated in structured particles by membrane emulsification. Two different configurations of integrated membrane processes were studied. In the first one, a BMR unit was combined with two membrane emulsification (ME) units (one for extraction of oleuropein aglycone using a green solvent and one for its formulation) obtaining the encapsulation of oleuropein aglycone in solid lipid particles. Instead in the other configuration, BMR was combined with one ME unit and OA-loaded poly(vinyl alcohol) (PVA) particles were produced. The non-commercially available oleuropein aglycone was produced in the BMR with a conversion of 40% at each passage of the substrate through the system. Regarding the production of particles loaded with biophenols, uniform particles with high encapsulation efficiency up to 98% were produced under mild operating conditions. References [1] E. Piacentini, R. Mazzei, F. Bazzarelli, G. Ranieri, T. Poerio, L. Giorno. Oleuropein Aglycone Production and Formulation by Integrated Membrane Process. Industrial & Engineering Chemistry Research, 58.36 (2019) 16813-16822. Acknowledgments The authors acknowledge for the financial support the project PON01_01545, Olio più, within the framework PON Ricerca e Competitività 2007-2013.
Valorization of olive leaves by bioproduction and formulation of high-added value compounds
F Bazzarelli;E Piacentini;R Mazzei;G Ranieri;T Poerio;L Giorno
2019
Abstract
The olive leaves represent a rich source of biophenols with pharmaceutical and nutraceutical activities. This biomass is a renewable material from which important phytotherapics such as oleuropein, rutin and verbascoside can be extracted. The development of environmentally friendly strategies for the valorization of biomass is of crucial importance in view of a circular economy. In this work, the bioconversion of oleuropein to produce oleuropein aglycone (OA) and its encapsulation in particles was investigated by an integrated membrane process. The biocatalytic membrane reactor (BMR) has been studied for the production of oleuropein aglycone using oleuropein contained in olive leaves extract [1]. Subsequently, oleuropein aglycone was encapsulated in structured particles by membrane emulsification. Two different configurations of integrated membrane processes were studied. In the first one, a BMR unit was combined with two membrane emulsification (ME) units (one for extraction of oleuropein aglycone using a green solvent and one for its formulation) obtaining the encapsulation of oleuropein aglycone in solid lipid particles. Instead in the other configuration, BMR was combined with one ME unit and OA-loaded poly(vinyl alcohol) (PVA) particles were produced. The non-commercially available oleuropein aglycone was produced in the BMR with a conversion of 40% at each passage of the substrate through the system. Regarding the production of particles loaded with biophenols, uniform particles with high encapsulation efficiency up to 98% were produced under mild operating conditions. References [1] E. Piacentini, R. Mazzei, F. Bazzarelli, G. Ranieri, T. Poerio, L. Giorno. Oleuropein Aglycone Production and Formulation by Integrated Membrane Process. Industrial & Engineering Chemistry Research, 58.36 (2019) 16813-16822. Acknowledgments The authors acknowledge for the financial support the project PON01_01545, Olio più, within the framework PON Ricerca e Competitività 2007-2013.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
