Reduction of different organohalides, bromonucleosides among them, was successfully carried Out in yields ranging from 75% to quantitative, using (TMS)(3)SiH in a heterogeneous system with water as the solvent. Our procedure, employing 2-mercaptoethanol as the catalyst and the hydrophobic diazo-compound ACCN as the initiator, illustrates that (TMS)(3)SiH can be the radical-based reducing agent of choice in aqueous medium. (TMS)(3)SiH does not suffer from any significant reaction with water and can safely be used with additional benefit, such as ease of purification and environmental compatibility.
The radical-based reduction with (TMS)3SiH on water
Ferreri C;Navacchia M L;Chatgilialoglu C
2005
Abstract
Reduction of different organohalides, bromonucleosides among them, was successfully carried Out in yields ranging from 75% to quantitative, using (TMS)(3)SiH in a heterogeneous system with water as the solvent. Our procedure, employing 2-mercaptoethanol as the catalyst and the hydrophobic diazo-compound ACCN as the initiator, illustrates that (TMS)(3)SiH can be the radical-based reducing agent of choice in aqueous medium. (TMS)(3)SiH does not suffer from any significant reaction with water and can safely be used with additional benefit, such as ease of purification and environmental compatibility.File in questo prodotto:
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