Antonucci et al. demonstrate that a primary increase in superoxide selectively within the mitochondria directly impacts on mitochondrial and cell function. Moreover, a slight increase in mitochondrial ROS is protective against cardiac ischaemia-reperfusion injury despite negative effects at higher concentrations.
Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis
Kaludercic N;Di Lisa F;
2019
Abstract
Antonucci et al. demonstrate that a primary increase in superoxide selectively within the mitochondria directly impacts on mitochondrial and cell function. Moreover, a slight increase in mitochondrial ROS is protective against cardiac ischaemia-reperfusion injury despite negative effects at higher concentrations.File in questo prodotto:
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