Sam Domains in Multiple Diseases

The sterile alpha motif (Sam) domain is a small helical protein module able to undergo homo- and heterooligomerization as well as polymerization thus forming different types of protein architectures. A few Sam domains are involved in pathological processes and consequently, they represent valuable targets for the development of new potential therapeutic routes. This study intends to collect state-of-the-art knowledge on the different modes by which Sam domains can favor disease onset and progression