Calcium dysregulation, membrane leakage and Ab amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca2+ ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathies
The active role of Ca2+ ions in A?-mediated membrane damage
Sciacca MFM;Milardi D
2018
Abstract
Calcium dysregulation, membrane leakage and Ab amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca2+ ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathiesFile in questo prodotto:
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