In this chapter we describe: (1) the procedure for the synthesis of four single chain bolaamphiphiles,displaying chains of 12, 16, 20 and 30 methylene units and triphenylphosphonium moieties as headgroups(TPP1-TPP4); (2) the methods used to characterize TPP1-TPP4 spontaneous aggregation in aqueoussolution. We illustrate the determination of Krafft point and cac by conductivity measurements and theprocedures used to investigate dimensions, morphology, and stability by dynamic and dielectrophoreticlaser light scattering, dialysis, transmission electron microscopy, and Raman spectroscopy measurements.
Synthesis and Characterization of Mitochondria-Targeted Triphenylphosphonium Bolaamphiphiles
Francesca Ceccacci;Simona Sennato;Valentina Mussi;Federico Bordi;Giovanna Mancini;Cecilia Bombelli
2021
Abstract
In this chapter we describe: (1) the procedure for the synthesis of four single chain bolaamphiphiles,displaying chains of 12, 16, 20 and 30 methylene units and triphenylphosphonium moieties as headgroups(TPP1-TPP4); (2) the methods used to characterize TPP1-TPP4 spontaneous aggregation in aqueoussolution. We illustrate the determination of Krafft point and cac by conductivity measurements and theprocedures used to investigate dimensions, morphology, and stability by dynamic and dielectrophoreticlaser light scattering, dialysis, transmission electron microscopy, and Raman spectroscopy measurements.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
prod_454768-doc_175441.pdf
solo utenti autorizzati
Descrizione: Synthesis and Characterization of Mitochondria-Targeted Triphenylphosphonium Bolaamphiphiles
Tipologia:
Versione Editoriale (PDF)
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
686.32 kB
Formato
Adobe PDF
|
686.32 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
1.pdf
accesso aperto
Descrizione: Mitochondrial Medicine
Tipologia:
Documento in Pre-print
Licenza:
Altro tipo di licenza
Dimensione
505.46 kB
Formato
Adobe PDF
|
505.46 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
