Extracellular vesicles are important biomarkers and therapeutic targets for breast cancer (BC). However, specific tools for their recognition are lacking. Condorelli and colleagues describe the finding of a high-affinity aptamer (ex-50.T) able to specifically target BC exosomes acting as a promising diagnostic and therapeutic tool.

Identification of a novel RNA aptamer that selectively targets breast cancer exosomes

Esposito Carla Lucia;Quintavalle Cristina;Rotoli Deborah;Catuogno Silvia;de Franciscis Vittorio;Condorelli Gerolama
2021

Abstract

Extracellular vesicles are important biomarkers and therapeutic targets for breast cancer (BC). However, specific tools for their recognition are lacking. Condorelli and colleagues describe the finding of a high-affinity aptamer (ex-50.T) able to specifically target BC exosomes acting as a promising diagnostic and therapeutic tool.
2021
Istituto di Endocrinologia e Oncologia Sperimentale ''G. Salvatore'' - IEOS
aptamers
blood
breast cancer
early diagnosis
exosomes
identification
liquid biopsy
SELEX
serum markers
therapy
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/401728
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 34
  • ???jsp.display-item.citation.isi??? ND
social impact