Objective: To understand the genetic determinants of pancreatic beta-cell glucose sensitivity using genome-wide meta-analysis and candidate gene studies.
Context: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity.
Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity
Tura Andrea;Ferrannini Ele;Mari Andrea;
2021
Abstract
Context: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity.File in questo prodotto:
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Descrizione: Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity
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