Background: Major Depressive Disorder (MDD) is a psychiatric illness that is often associated with potentially life -threatening physiological changes and increased risk for suicidal behavior. Electroencephalography (EEG) research suggests an association between depression and specific frequency imbalances in the frontal brain re-gion. Further, while recently developed technology has been proposed to simplify EEG data acquisition, more research is still needed to support its use in patients with MDD.Methods: Using the 14-channel EMOTIV EPOC cap, we recorded resting state EEG from 15 MDD patients with suicidal ideation (SI) vs. 12 healthy controls (HC) to investigate putative power spectral density (PSD) between -group differences at the F3 and F4 electrode sites. Specifically, we explored 1) between-group alpha power asymmetries (AA), 2) between-group differences in delta, theta, alpha and beta power, 3) correlations between PSD data and scores in the Beck's Depression Inventory-II (BDI-II), Beck's Anxiety Inventory (BAI), Reasons for Living Inventory (RFL), and Self-Disgust Questionnaire (SDS).Results: When compared to HC, patients had higher scores on the BAI (p = 0.0018), BDI-II (p = 0.0001) or SDS (p = 0.0142) scale and lower scores in the RFL (p = 0.0006) scale. The PSD analysis revealed no between-group difference or correlation with questionnaire scores for any of the measures considered.Conclusions: The present study could not confirm previous research suggesting frequency-specific anomalies in depressed persons with SI but might suggest that frontal EEG imbalances reflect greater anxiety and negative self -referencing. Future studies should confirm these findings in a larger population sample.

A resting state EEG study on depressed persons with suicidal ideation

De Canditiis Daniela;Castiglione Filippo;Pascarella Annalisa;
2023

Abstract

Background: Major Depressive Disorder (MDD) is a psychiatric illness that is often associated with potentially life -threatening physiological changes and increased risk for suicidal behavior. Electroencephalography (EEG) research suggests an association between depression and specific frequency imbalances in the frontal brain re-gion. Further, while recently developed technology has been proposed to simplify EEG data acquisition, more research is still needed to support its use in patients with MDD.Methods: Using the 14-channel EMOTIV EPOC cap, we recorded resting state EEG from 15 MDD patients with suicidal ideation (SI) vs. 12 healthy controls (HC) to investigate putative power spectral density (PSD) between -group differences at the F3 and F4 electrode sites. Specifically, we explored 1) between-group alpha power asymmetries (AA), 2) between-group differences in delta, theta, alpha and beta power, 3) correlations between PSD data and scores in the Beck's Depression Inventory-II (BDI-II), Beck's Anxiety Inventory (BAI), Reasons for Living Inventory (RFL), and Self-Disgust Questionnaire (SDS).Results: When compared to HC, patients had higher scores on the BAI (p = 0.0018), BDI-II (p = 0.0001) or SDS (p = 0.0142) scale and lower scores in the RFL (p = 0.0006) scale. The PSD analysis revealed no between-group difference or correlation with questionnaire scores for any of the measures considered.Conclusions: The present study could not confirm previous research suggesting frequency-specific anomalies in depressed persons with SI but might suggest that frontal EEG imbalances reflect greater anxiety and negative self -referencing. Future studies should confirm these findings in a larger population sample.
2023
Istituto Applicazioni del Calcolo ''Mauro Picone''
Electroencephalogram
EEG
Depression
Anxiety
Suicidal ideation
Emotiv epoc
File in questo prodotto:
File Dimensione Formato  
pubblished_IBRO_Neur_report2023.pdf

solo utenti autorizzati

Tipologia: Versione Editoriale (PDF)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 733.38 kB
Formato Adobe PDF
733.38 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/433824
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact