Parkinson disease (PD) is among the most common human neurodegenerative diseases and it is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (SN), with concomitant accumulation of typical cytoplasmic inclusions called Lewy bodies (LB). Several protein components are detected in these insoluble aggregates, including alpha-synuclein, parkin and the putative G-protein coupled membrane receptor 37 (GPR37).
Macroautophagy of the GPR37 orphan receptor and Parkinson disease-associated neurodegeneration
Daniela Marazziti;Chiara Di Pietro;Elisabetta Golini;Silvia Mandillo;Rafaele Matteoni;
2009
Abstract
Parkinson disease (PD) is among the most common human neurodegenerative diseases and it is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (SN), with concomitant accumulation of typical cytoplasmic inclusions called Lewy bodies (LB). Several protein components are detected in these insoluble aggregates, including alpha-synuclein, parkin and the putative G-protein coupled membrane receptor 37 (GPR37).File in questo prodotto:
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