The use of photodynamics in dermatology is emerging as new and alternative therapy in anti-cancer treatments, and in many other diseases and defects, as wounds repair and rejuvenation. The challenging applications of these therapies rely in their immunomodulatory, antibacterial, and regenerative properties. At low energy density, photosensitizers enable specific cell/tissue and/or organs response to photostimulation. Polymeric biodegradable membranes as porous barriers provide protection of skin damages ensuring oxygenation and repair. Moreover, as biomimetic microenvironments, membranes represent appealing biomaterials for tissue engineering and regeneration. In this study a biodegradable and microporous composite membrane of chitosan (CHT) and porphyrin was developed as a potential patch for the treatment of skin diseases. CHT membranes have previously been developed and tested as promising biomaterials for dermal and epidermal skin reconstruction [1, 2]. The composite membrane was developed by incorporating in the CHT polymeric solution a photosensitizing nanosystem, based on the cationic porphyrin 5,10,15,20-tetrakis (N-methyl-4-pyridyl)-21H,23H-porphyrin (TMPyP) complexed with the commerical sulfobutyletherbeta-cyclodextrin (CAPTISOL®) [3]. The CHT/CAPTISOL®-TMPyP composite membrane shows a peculiar porous microstructure and evidences a significative antimicrobial activity, opening new insight for skin disease treatments with photodynamic therapy.The use of photodynamics in dermatology is emerging as new and alternative therapy in anti-cancer treatments, and in many other diseases and defects, as wounds repair and rejuvenation. The challenging applications of these therapies rely in their immunomodulatory, antibacterial, and regenerative properties. At low energy density, photosensitizers enable specific cell/tissue and/or organs response to photostimulation. Polymeric biodegradable membranes as porous barriers provide protection of skin damages ensuring oxygenation and repair. Moreover, as biomimetic microenvironments, membranes represent appealing biomaterials for tissue engineering and regeneration. In this study a biodegradable and microporous composite membrane of chitosan (CHT) and porphyrin was developed as a potential patch for the treatment of skin diseases. CHT membranes have previously been developed and tested as promising biomaterials for dermal and epidermal skin reconstruction [1, 2]. The composite membrane was developed by incorporating in the CHT polymeric solution a photosensitizing nanosystem, based on the cationic porphyrin 5,10,15,20-tetrakis (N-methyl-4-pyridyl)-21H,23H-porphyrin (TMPyP) complexed with the commerical sulfobutyletherbeta-cyclodextrin (CAPTISOL®) [3]. The CHT/CAPTISOL®-TMPyP composite membrane shows a peculiar porous microstructure and evidences a significative antimicrobial activity, opening new insight for skin disease treatments with photodynamic therapy.
Chitosan-Porphyrin Composite Membrane for Topical Photodynamic Therapy
Simona Salerno
Primo
;Roberto Zagami;Mariachiara Trapani;Loredana De Bartolo;Antonino Mazzaglia
2024
Abstract
The use of photodynamics in dermatology is emerging as new and alternative therapy in anti-cancer treatments, and in many other diseases and defects, as wounds repair and rejuvenation. The challenging applications of these therapies rely in their immunomodulatory, antibacterial, and regenerative properties. At low energy density, photosensitizers enable specific cell/tissue and/or organs response to photostimulation. Polymeric biodegradable membranes as porous barriers provide protection of skin damages ensuring oxygenation and repair. Moreover, as biomimetic microenvironments, membranes represent appealing biomaterials for tissue engineering and regeneration. In this study a biodegradable and microporous composite membrane of chitosan (CHT) and porphyrin was developed as a potential patch for the treatment of skin diseases. CHT membranes have previously been developed and tested as promising biomaterials for dermal and epidermal skin reconstruction [1, 2]. The composite membrane was developed by incorporating in the CHT polymeric solution a photosensitizing nanosystem, based on the cationic porphyrin 5,10,15,20-tetrakis (N-methyl-4-pyridyl)-21H,23H-porphyrin (TMPyP) complexed with the commerical sulfobutyletherbeta-cyclodextrin (CAPTISOL®) [3]. The CHT/CAPTISOL®-TMPyP composite membrane shows a peculiar porous microstructure and evidences a significative antimicrobial activity, opening new insight for skin disease treatments with photodynamic therapy.The use of photodynamics in dermatology is emerging as new and alternative therapy in anti-cancer treatments, and in many other diseases and defects, as wounds repair and rejuvenation. The challenging applications of these therapies rely in their immunomodulatory, antibacterial, and regenerative properties. At low energy density, photosensitizers enable specific cell/tissue and/or organs response to photostimulation. Polymeric biodegradable membranes as porous barriers provide protection of skin damages ensuring oxygenation and repair. Moreover, as biomimetic microenvironments, membranes represent appealing biomaterials for tissue engineering and regeneration. In this study a biodegradable and microporous composite membrane of chitosan (CHT) and porphyrin was developed as a potential patch for the treatment of skin diseases. CHT membranes have previously been developed and tested as promising biomaterials for dermal and epidermal skin reconstruction [1, 2]. The composite membrane was developed by incorporating in the CHT polymeric solution a photosensitizing nanosystem, based on the cationic porphyrin 5,10,15,20-tetrakis (N-methyl-4-pyridyl)-21H,23H-porphyrin (TMPyP) complexed with the commerical sulfobutyletherbeta-cyclodextrin (CAPTISOL®) [3]. The CHT/CAPTISOL®-TMPyP composite membrane shows a peculiar porous microstructure and evidences a significative antimicrobial activity, opening new insight for skin disease treatments with photodynamic therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
