The findings described in this article uncover a novel mechanism by which BoNT/A-mediated SNAP25 cleavage in Schwann cells lifts inhibitory signaling constraints, sustains a reparative state, and creates a permissive environment for axonal regrowth, significantly supporting peripheral nerve regeneration..
SNAP25 CLEAVAGE BY BOTULINUM NEUROTOXIN-A REPROGRAMS SCHWANN CELLS INTO A PROREGENERATIVE PHENOTYPE
V. Mastrorilli;F. De Angelis;S. Luvisetto;S. Marinelli
2025
Abstract
The findings described in this article uncover a novel mechanism by which BoNT/A-mediated SNAP25 cleavage in Schwann cells lifts inhibitory signaling constraints, sustains a reparative state, and creates a permissive environment for axonal regrowth, significantly supporting peripheral nerve regeneration..File in questo prodotto:
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