Both enantiomers of trans-2,3-cis-3,4-dihydroxyproline, 4 and 5, have been stereoselectively synthesized from 2,3-O-isopropylidene-D-glyceraldehyde 1, by taking advantage of a divergent and parallel synthetic strategy, utilizing N-(tert-butoxycarbonyl)-2-(tertbutyldimethylsiloxy) pyrrole (TBSOP) as the common four-carbon synthon.
Total Synthesis of Both Enantiomers of trans-2,3-cis-3,4- Dihydroxyproline
Pietro Spanu;
1996
Abstract
Both enantiomers of trans-2,3-cis-3,4-dihydroxyproline, 4 and 5, have been stereoselectively synthesized from 2,3-O-isopropylidene-D-glyceraldehyde 1, by taking advantage of a divergent and parallel synthetic strategy, utilizing N-(tert-butoxycarbonyl)-2-(tertbutyldimethylsiloxy) pyrrole (TBSOP) as the common four-carbon synthon.File in questo prodotto:
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