CNR Institutional Research Information System

DE SIMONE, GIUSEPPINA
 Distribuzione geografica
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Continente #
AS - Asia 4.299
NA - Nord America 1.994
EU - Europa 921
SA - Sud America 814
AF - Africa 72
OC - Oceania 7
Continente sconosciuto - Info sul continente non disponibili 2
Totale 8.109
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Nazione #
US - Stati Uniti d'America 1.897
SG - Singapore 1.749
CN - Cina 1.083
BR - Brasile 662
HK - Hong Kong 443
VN - Vietnam 373
IT - Italia 245
FR - Francia 227
KR - Corea 206
JP - Giappone 101
NL - Olanda 95
IN - India 82
DE - Germania 63
GB - Regno Unito 63
FI - Finlandia 62
BD - Bangladesh 57
AR - Argentina 56
CA - Canada 39
MX - Messico 30
ID - Indonesia 28
IQ - Iraq 28
PL - Polonia 28
IL - Israele 26
EC - Ecuador 25
ZA - Sudafrica 22
RU - Federazione Russa 18
MA - Marocco 16
VE - Venezuela 16
ES - Italia 15
SA - Arabia Saudita 15
UZ - Uzbekistan 14
CO - Colombia 13
PK - Pakistan 13
UA - Ucraina 13
TR - Turchia 12
CL - Cile 11
PE - Perù 11
PY - Paraguay 11
SE - Svezia 11
KE - Kenya 10
IE - Irlanda 9
AT - Austria 8
CZ - Repubblica Ceca 8
UY - Uruguay 8
AZ - Azerbaigian 7
LB - Libano 7
BG - Bulgaria 6
CH - Svizzera 6
PH - Filippine 6
TN - Tunisia 6
TW - Taiwan 6
AL - Albania 5
AU - Australia 5
EG - Egitto 5
JM - Giamaica 5
JO - Giordania 5
KZ - Kazakistan 5
LT - Lituania 5
DK - Danimarca 4
GR - Grecia 4
HN - Honduras 4
NP - Nepal 4
SV - El Salvador 4
AM - Armenia 3
BA - Bosnia-Erzegovina 3
BY - Bielorussia 3
DO - Repubblica Dominicana 3
DZ - Algeria 3
MY - Malesia 3
PT - Portogallo 3
SN - Senegal 3
AE - Emirati Arabi Uniti 2
BE - Belgio 2
BH - Bahrain 2
CI - Costa d'Avorio 2
CR - Costa Rica 2
EE - Estonia 2
HR - Croazia 2
HT - Haiti 2
HU - Ungheria 2
KW - Kuwait 2
LK - Sri Lanka 2
LV - Lettonia 2
MM - Myanmar 2
MN - Mongolia 2
NO - Norvegia 2
OM - Oman 2
PA - Panama 2
TJ - Tagikistan 2
BO - Bolivia 1
CD - Congo 1
CW - ???statistics.table.value.countryCode.CW??? 1
DM - Dominica 1
GA - Gabon 1
GT - Guatemala 1
KG - Kirghizistan 1
KH - Cambogia 1
KN - Saint Kitts e Nevis 1
LA - Repubblica Popolare Democratica del Laos 1
MD - Moldavia 1
Totale 8.092
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Città #
Singapore 1.065
Santa Clara 655
Hefei 463
Hong Kong 432
San Jose 323
Seoul 204
Beijing 193
Lauterbourg 191
Los Angeles 134
Ashburn 129
Ho Chi Minh City 112
Hanoi 92
Dallas 70
Tokyo 66
São Paulo 64
Naples 62
New York 35
Helsinki 34
Casandrino 26
Minamishinagawa 26
Frankfurt am Main 25
Lappeenranta 24
Warsaw 23
Bengaluru 22
Da Nang 22
Orem 22
Buffalo 19
Montreal 19
London 18
Rio de Janeiro 18
Amsterdam 17
Düsseldorf 15
Haiphong 15
Belo Horizonte 14
Johannesburg 14
Tashkent 14
Shanghai 13
Florence 12
Rome 12
Baghdad 11
Curitiba 11
Chennai 10
Nairobi 10
Phoenix 10
Portsmouth 10
Guarulhos 9
Hải Dương 9
Mexico City 9
Milan 9
Mumbai 9
Quito 9
Riyadh 9
Salvador 9
Stockholm 9
Atlanta 8
Brasília 8
Brooklyn 8
Buenos Aires 8
Chicago 8
Dhaka 8
Fortaleza 8
Ninh Bình 8
Porto Alegre 8
Baku 7
Campinas 7
Dublin 7
Guayaquil 7
Houston 7
Nha Trang 7
Ribeirão Preto 7
Santiago 7
Caracas 6
Casablanca 6
Falkenstein 6
Maracaibo 6
Montevideo 6
Phủ Lý 6
Sofia 6
Vienna 6
Afragola 5
Agra 5
Amman 5
Ankara 5
Biên Hòa 5
Bogotá 5
Charlotte 5
Cuiabá 5
Guangzhou 5
Juiz de Fora 5
Lima 5
Santo André 5
Shenzhen 5
Sydney 5
Toronto 5
Valašské Meziříčí 5
Valparaíso de Goiás 5
Vũng Tàu 5
Aracaju 4
Asunción 4
Boardman 4
Totale 5.135
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Nome #
Inhibition of carbonic anhydrases IX/XII by SLC-0111 boosts cisplatin effects in hampering head and neck squamous carcinoma cell growth and invasion 118
Z-Carbonic anhydrases 105
Kinetic and anion inhibition studies of a beta-carbonic anhydrase (FbiCA 1) from the C-4 plant Flaveria bidentis 92
α-CAs from Photosynthetic Organisms 90
Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia 83
2-Mercaptobenzoxazoles: a class of carbonic anhydrase inhibitors with a novel binding mode to the enzyme active site 80
Carbonic anhydrase IX subcellular localization in normoxic and hypoxic SH-SY5Y neuroblastoma cells is assisted by its C-terminal protein interaction domain 77
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib. 77
Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII 77
Catechols: a new class of carbonic anhydrase inhibitors 76
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. 73
THE CRYSTAL STRUCTURE OF HCA I/TOPIRAMATE COMPLEX PROVIDES USEFUL INSIGHTS INTO RATIONAL DRUG DESIGN OF ANTI-OBESITY DRUGS 72
Benzyl alcohol inhibits carbonic anhydrases by anchoring to the zinc coordinated water molecule 72
Carbonic Anhydrase Inhibitors. Comparison of Aliphatic Sulfamate/Bis-sulfamate Adducts with Isozymes II and IX as a Platform for Designing Tight-Binding, More Isoform-Selective Inhibitors 69
Biochemical and Structural Insights into the Winged Helix Domain of P150, the Largest Subunit of the Chromatin Assembly Factor 1 69
6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography 67
Structure and inhibition insights into Carbonic anhydrase CDCA1 from marine diatom Thalassiosira Weissflogii. 66
Thermostable carbonic anhydrases in biotechnological applications 66
Intrinsically disordered features of carbonic anhydrase IX proteoglycan-like domain 66
Inhibition of the newly discovered ?-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules 65
Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII. 64
L-Histidinol Dehydrogenase as a New Target for Old Diseases 64
Biochemical, structural, and computational studies of a ?-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei 62
A Combined in Silico and Structural Study Opens New Perspectives on Aliphatic Sulfonamides, a Still Poorly Investigated Class of CA Inhibitors 62
A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity 62
Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors 61
Structural basis for the rational design of new antibrucella agents 60
Bacterial α-CAs: a biochemical and structural overview 60
Design, synthesis and characterization of a peptide able to bind proteins of the KCTD family: implications for KCTD-cullin 3 recognition 59
ALPHA-CARBONIC ANHYDRASES 59
Inhibition of Bone Marrow-Mesenchymal Stem Cell-Induced Carbonic Anhydrase IX Potentiates Chemotherapy Efficacy in Triple-Negative Breast Cancer Cells 59
Zeta-carbonic anhydrases show CS2 hydrolase activity: A new metabolic carbon acquisition pathway in diatoms? 59
Human carbonic Anydrase VII protects cells from oxidative damage 58
X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design 58
Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target. 57
Faox enzymes inhibited Maillard reaction development during storage both in protein glucose model system and low lactose UHT milk. 57
A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases 57
Eta- and teta-carbonic anhydrase 57
Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors 56
Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase fromTrichomonas vaginalis 56
The crystal structures of 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II and VII provide insights into selective CA inhibitor development 55
Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches 55
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain 54
Crystal structure of an S-formylglutathione hydrolase from pseudoalteromonas haloplanktis TAC125. 54
Exploring the binding mode of phenyl and vinyl boronic acids to human carbonic anhydrases 53
Antiobesity carbonic anhydrase inhibitors 52
Structural study of the Carbonic Anhydrase SazCA from the thermophilic bacterium Sulfurihydrogenibium Azorense 52
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl) benzenesulfonamide moiety 52
The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior 51
Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX 51
Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense 50
A NEW LEAD COMPOUND FOR THE DEVELOPMENT OF CARBONIC ANHYDRASE INHIBITORS 50
Saccharomyces cerevesiae, Candida spp. and Cryptococcus neoformans β-CAs 50
Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach 49
Editorial: Emerging advancements in the carbonic anhydrase field 49
The Amazing World of IDPs in Human Diseases II 49
Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme selectivity 48
Human Carbonic Anhydrases and Post-Translational Modifications: A Hidden World Possibly Affecting Protein Properties and Functions 48
The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies 48
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy 47
Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms 47
Biochemical and Structural Insights into Carbonic Anhydrase XII/Fab6A10 Complex 46
Zeta-Carbonic anhydrases 46
Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one 45
Post-translational modifications in tumor-associated carbonic anhydrases 44
Functional and structural features of the oxyanion hole in a thermophilic esterase from Alicyclobacillus acidocaldarius 44
Recent Advances in the Development of New Therapeutic Tools Against Major Parasitic Diseases 44
Carbonic Anhydrase II as Target for Drug Design 43
Are Carbonic Anhydrases Suitable Targets to Fight Protozoan Parasitic Diseases? 43
Disclosing the interaction of carbonic anhydrase ix with cullin-associated nedd8-dissociated protein 1 by molecular modeling and integrated binding measurements. 42
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy 41
C68 from the Sulfolobus islandicus plasmid-virus pSSVx is a novelmember of the AbrB-like transcription factor family 41
Sulfolobus solfataricus thiol redox puzzle: Characterization of an atypical protein disulfide oxidoreductase 41
Structural and inhibition insights into carbonic anhydrase CDCA1 from the marine diatom Thalassiosira weissflogii 41
Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment 41
Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides 41
Bacterial Metallo-Enzymes as Drug Targets 41
The crystal structure of a hyper-thermophilic carboxylesterase from the Archaeon Archaeoglobus fulgidus 40
Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? 40
X-ray structure of the first 'extremo-alfa-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 40
Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis. 40
Depsides from Origanum dictamnus and Satureja pilosa as selective inhibitors of carbonic anhydrases: Isolation, structure elucidation, X‐ray crystallography 39
Carbonic Anhydrases as new targets against the bacterial pathogen Brucella suis 38
Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding 38
Out of the active site binding pocket for carbonic anhydrase inhibitors 38
Multiple Binding Modes of Inhibitors to Human Carbonic Anhydrases: An Update on the Design of Isoform-Specific Modulators of Activity 37
Anticancer drugs: where are we now? 37
The Amazing World of IDPs in Human Diseases 37
Fungal α-carbonic anhydrases 37
An integrated structural and computational study of the thermostability of two thioredoxin mutants from Alicyclobacillus acidocaldarius 37
Cadmium-containing carbonic anhydrase CDCA1 in marine diatom Thalassiosira weissflogii 37
A CUL3-DERIVED PEPTIDE BINDING DIFFERENT MEMBERS OF THE KCTD FAMILY 37
Human Carbonic Anhydrases:Catalytic Properties, Structural Features, and Tissue Distribution 36
Biochemical and structural insights into hystidinol dehydrogenase from Brucella suis. 36
Protective Role of Carbonic Anhydrases III and VII in Cellular Defense Mechanisms upon Redox Unbalance 36
Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor 36
A new role of Human Carbonic Anhydrase VII in the protection of the cells from oxidative damage 36
A substrate-induced switch in the reaction mechanism of a thermophilic esterase. Kinetic evidences and structutal basis 35
Structural insights into Carbonic anhydrase CDCA1 from marine diatom Thalassiosira Weissflogii 35
Benzoxaborole as a new chemotype for carbonic anhydrase inhibition 35
Totale 5.352
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Categoria #
all - tutte 27.334
article - articoli 19.872
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 2.145
Totale 49.351
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2023/202465 0 0 0 0 0 0 0 0 12 4 44 5
2024/20253.103 34 21 316 125 628 112 58 166 125 141 730 647
2025/20265.169 292 536 497 757 885 345 760 250 285 330 232 0
Totale 8.337