TRAMONTI, ANGELA
TRAMONTI, ANGELA
Istituto di Biologia e Patologia Molecolari - IBPM
Identification of the pyridoxal 5?-phosphate allosteric site in human pyridox(am)ine 5?-phosphate oxidase
2024 Barile, Anna; Graziani, Claudio; Antonelli, Lorenzo; Parroni, Alessia; Fiorillo, Annarita; Luigi di Salvo, Martino; Ilari, Andrea; Giorgi, Alessandra; Rosignoli, Serena; Paiardini, Alessandro; Contestabile, Roberto; Tramonti, Angela
One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse
2024 Malatesta, Marco; Fornasier, Emanuele; Di Salvo, Martino Luigi; Tramonti, Angela; Zangelmi, Erika; Peracchi, Alessio; Secchi, Andrea; Polverini, Eugenia; Giachin, Gabriele; Battistutta, Roberto; Contestabile, Roberto; Percudani, Riccardo
Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1
2024 Spizzichino, Sharon; Di Fonzo, Federica; Marabelli, Chiara; Tramonti, Angela; Chaves-Sanjuan, Antonio; Parroni, Alessia; Boumis, Giovanna; Liberati, Francesca Romana; Paone, Alessio; Montemiglio, Linda Celeste; Ardini, Matteo; Jakobi, Arjen J.; Bharadwaj, Alok; Swuec, Paolo; Tartaglia, Gian Gaetano; Paiardini, Alessandro; Contestabile, Roberto; Mai, Antonello; Rotili, Dante; Fiorentino, Francesco; Macone, Alberto; Giorgi, Alessandra; Tria, Giancarlo; Rinaldo, Serena; Bolognesi, Martino; Giardina, Giorgio; Cutruzzolà, Francesca
The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target
2024 Graziani, Claudio; Barile, Anna; Antonelli, Lorenzo; Fiorillo, Annarita; Ilari, Andrea; Vetica, Fabrizio; di Salvo, Martino Luigi; Paiardini, Alessandro; Tramonti, Angela; Contestabile, Roberto
Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila
2024 Pilesi, Eleonora; Tesoriere, Giulia; Ferriero, Angelo; Mascolo, Elisa; Liguori, Francesco; Argirò, Luca; Angioli, Chiara; Tramonti, Angela; Contestabile, Roberto; Volonté, Cinzia; Vernì, Fiammetta
4'-Deoxypyridoxine disrupts vitamin B6 homeostasis in Escherichia coli K12 through combined inhibition of cumulative B6 uptake and PLP-dependent enzyme activity
2023 Babor, Jill; Tramonti, Angela; Nardella, Caterina; Deutschbauer, Adam; Contestabile, Roberto; de CrécyLagard, Valérie
7ZLA: Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the half-closed conformation
2023 Freda I.; Montemiglio L.C.; Tramonti A.; Contestabile R.; Vallone B.; Savino C.; Exertier C.; Bolognesi M.; Chaves Sanjuan A.
7ZN5: Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the closed conformation, C2 symmetry
2023 Freda, I; Montemiglio, Lc; Tramonti, A; Contestabile, R; Vallone, B; Savino, C; Exertier, C; Bolognesi, M; Chaves Sanjuan, A
7ZPA: Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the closed conformation, C1 symmetry
2023 Freda, I; Montemiglio, Lc; Tramonti, A; Contestabile, R; Vallone, B; Savino, C; Exertier, C; Bolognesi, M; Chaves Sanjuan, A
7ZTH: Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the open conformation
2023 Freda, I; Montemiglio, Lc; Tramonti, A; Contestabile, R; Vallone, B; Savino, C; Exertier, C; Bolognesi, M; Chaves Sanjuan, A
A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila
2023 Pilesi, E; Angioli, C; Graziani, C; Parroni, A; Contestabile, R; Tramonti, A; Vernì, F
Diffusible signal factors (DSFs) bind and repress VirF, the leading virulence activator of Shigella flexneri
2023 Trirocco, Rita; Pasqua, Martina; Tramonti, Angela; Colonna, Bianca; Paiardini, Alessandro; Prosseda, Gianni
Fatty Acids Abolish Shigella Virulence by Inhibiting Its Master Regulator, VirF
2023 Trirocco, R; Pasqua, M; Tramonti, A; Grossi, M; Colonna, B; Paiardini, A; Prosseda, G
Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway
2023 Tramonti, Angela; Donkor Akua, K; Parroni, Alessia; Musayev Faik, N; Barile, Anna; Ghatge Mohini, S; Graziani, Claudio; Alkhairi, Mona; Alawadh, Mohammed; di Salvo Martino, Luigi; Safo Martin, K; Contestabile, Roberto
Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR
2023 Freda, I; Exertier, C; Barile, A; Chavessanjuan, A; Vega, Mv; Isupov, Mn; Harmer, Nj; Gugole, E; Swuec, P; Bolognesi, M; Scipioni, A; Savino, C; Di Salvo, Ml; Contestabile, R; Vallone, B; Tramonti, A; Montemiglio, Lc
Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives
2022 Nogues Gonzalez, Maria Isabel; Sekula, Bartosz; Angelaccio, Sebastiana; Grzechowiak, Marta; Tramonti, Angela; Contestabile, Roberto; Ruszkowski, Milosz
Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): role of lysine residues in PLP binding and protein stability
2022 Tramonti, A; Ghatge, Ms; Babor, Jt; Musayev, Fn; di Salvo, Ml; Barile, A; Colotti, G; Giorgi, A; Paredes, Sd; Donkor, Ak; Al Mughram, Mh; de CrécyLagard, V; Safo, Mk; Contestabile, R
Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the Rat Brain Metabolism Is Linked to Protein Glutarylation
2022 Boyko, Ai; Karlina, Is; Zavileyskiy, Lg; Aleshin, Va; Artiukhov, Av; Kaehne, T; Ksenofontov, Al; Ryabov, Si; Graf, Av; Tramonti, A; Bunik, Vi
Efficient Assay and Marker Significance of NAD+ in Human Blood
2022 Balashova, Nv; Zavileyskiy, Lg; Artiukhov, Av; Shaposhnikov, La; Sidorova, Op; Tishkov, Vi; Tramonti, A; Pometun, Aa; Bunik, Vi
Thiamine-dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo
2022 Bunik, Victoria; Aleshin, Vasily; Nogues, Isabel; Kähne, Thilo; Parroni, Alessia; Contestabile, Roberto; Salvo, Martino Luigi; Graf, Anastasia; Tramonti, Angela
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Identification of the pyridoxal 5?-phosphate allosteric site in human pyridox(am)ine 5?-phosphate oxidase | 1-gen-2024 | Barile, Anna; Graziani, Claudio; Antonelli, Lorenzo; Parroni, Alessia; Fiorillo, Annarita; Luigi di Salvo, Martino; Ilari, Andrea; Giorgi, Alessandra; Rosignoli, Serena; Paiardini, Alessandro; Contestabile, Roberto; Tramonti, Angela | |
| One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse | 1-gen-2024 | Malatesta, Marco; Fornasier, Emanuele; Di Salvo, Martino Luigi; Tramonti, Angela; Zangelmi, Erika; Peracchi, Alessio; Secchi, Andrea; Polverini, Eugenia; Giachin, Gabriele; Battistutta, Roberto; Contestabile, Roberto; Percudani, Riccardo | |
| Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1 | 1-gen-2024 | Spizzichino, Sharon; Di Fonzo, Federica; Marabelli, Chiara; Tramonti, Angela; Chaves-Sanjuan, Antonio; Parroni, Alessia; Boumis, Giovanna; Liberati, Francesca Romana; Paone, Alessio; Montemiglio, Linda Celeste; Ardini, Matteo; Jakobi, Arjen J.; Bharadwaj, Alok; Swuec, Paolo; Tartaglia, Gian Gaetano; Paiardini, Alessandro; Contestabile, Roberto; Mai, Antonello; Rotili, Dante; Fiorentino, Francesco; Macone, Alberto; Giorgi, Alessandra; Tria, Giancarlo; Rinaldo, Serena; Bolognesi, Martino; Giardina, Giorgio; Cutruzzolà, Francesca | |
| The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target | 1-gen-2024 | Graziani, Claudio; Barile, Anna; Antonelli, Lorenzo; Fiorillo, Annarita; Ilari, Andrea; Vetica, Fabrizio; di Salvo, Martino Luigi; Paiardini, Alessandro; Tramonti, Angela; Contestabile, Roberto | |
| Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila | 1-gen-2024 | Pilesi, Eleonora; Tesoriere, Giulia; Ferriero, Angelo; Mascolo, Elisa; Liguori, Francesco; Argirò, Luca; Angioli, Chiara; Tramonti, Angela; Contestabile, Roberto; Volonté, Cinzia; Vernì, Fiammetta | |
| 4'-Deoxypyridoxine disrupts vitamin B6 homeostasis in Escherichia coli K12 through combined inhibition of cumulative B6 uptake and PLP-dependent enzyme activity | 1-gen-2023 | Babor, Jill; Tramonti, Angela; Nardella, Caterina; Deutschbauer, Adam; Contestabile, Roberto; de CrécyLagard, Valérie | |
| 7ZLA: Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the half-closed conformation | 1-gen-2023 | Freda I.; Montemiglio L.C.; Tramonti A.; Contestabile R.; Vallone B.; Savino C.; Exertier C.; Bolognesi M.; Chaves Sanjuan A. | |
| 7ZN5: Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the closed conformation, C2 symmetry | 1-gen-2023 | Freda, I; Montemiglio, Lc; Tramonti, A; Contestabile, R; Vallone, B; Savino, C; Exertier, C; Bolognesi, M; Chaves Sanjuan, A | |
| 7ZPA: Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the closed conformation, C1 symmetry | 1-gen-2023 | Freda, I; Montemiglio, Lc; Tramonti, A; Contestabile, R; Vallone, B; Savino, C; Exertier, C; Bolognesi, M; Chaves Sanjuan, A | |
| 7ZTH: Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the open conformation | 1-gen-2023 | Freda, I; Montemiglio, Lc; Tramonti, A; Contestabile, R; Vallone, B; Savino, C; Exertier, C; Bolognesi, M; Chaves Sanjuan, A | |
| A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila | 1-gen-2023 | Pilesi, E; Angioli, C; Graziani, C; Parroni, A; Contestabile, R; Tramonti, A; Vernì, F | |
| Diffusible signal factors (DSFs) bind and repress VirF, the leading virulence activator of Shigella flexneri | 1-gen-2023 | Trirocco, Rita; Pasqua, Martina; Tramonti, Angela; Colonna, Bianca; Paiardini, Alessandro; Prosseda, Gianni | |
| Fatty Acids Abolish Shigella Virulence by Inhibiting Its Master Regulator, VirF | 1-gen-2023 | Trirocco, R; Pasqua, M; Tramonti, A; Grossi, M; Colonna, B; Paiardini, A; Prosseda, G | |
| Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway | 1-gen-2023 | Tramonti, Angela; Donkor Akua, K; Parroni, Alessia; Musayev Faik, N; Barile, Anna; Ghatge Mohini, S; Graziani, Claudio; Alkhairi, Mona; Alawadh, Mohammed; di Salvo Martino, Luigi; Safo Martin, K; Contestabile, Roberto | |
| Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR | 1-gen-2023 | Freda, I; Exertier, C; Barile, A; Chavessanjuan, A; Vega, Mv; Isupov, Mn; Harmer, Nj; Gugole, E; Swuec, P; Bolognesi, M; Scipioni, A; Savino, C; Di Salvo, Ml; Contestabile, R; Vallone, B; Tramonti, A; Montemiglio, Lc | |
| Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives | 1-gen-2022 | Nogues Gonzalez, Maria Isabel; Sekula, Bartosz; Angelaccio, Sebastiana; Grzechowiak, Marta; Tramonti, Angela; Contestabile, Roberto; Ruszkowski, Milosz | |
| Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): role of lysine residues in PLP binding and protein stability | 1-gen-2022 | Tramonti, A; Ghatge, Ms; Babor, Jt; Musayev, Fn; di Salvo, Ml; Barile, A; Colotti, G; Giorgi, A; Paredes, Sd; Donkor, Ak; Al Mughram, Mh; de CrécyLagard, V; Safo, Mk; Contestabile, R | |
| Delayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the Rat Brain Metabolism Is Linked to Protein Glutarylation | 1-gen-2022 | Boyko, Ai; Karlina, Is; Zavileyskiy, Lg; Aleshin, Va; Artiukhov, Av; Kaehne, T; Ksenofontov, Al; Ryabov, Si; Graf, Av; Tramonti, A; Bunik, Vi | |
| Efficient Assay and Marker Significance of NAD+ in Human Blood | 1-gen-2022 | Balashova, Nv; Zavileyskiy, Lg; Artiukhov, Av; Shaposhnikov, La; Sidorova, Op; Tishkov, Vi; Tramonti, A; Pometun, Aa; Bunik, Vi | |
| Thiamine-dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo | 1-gen-2022 | Bunik, Victoria; Aleshin, Vasily; Nogues, Isabel; Kähne, Thilo; Parroni, Alessia; Contestabile, Roberto; Salvo, Martino Luigi; Graf, Anastasia; Tramonti, Angela |