Antioxidant activity (AA) of Lisosan G, a food supplement obtained from wheat grains, was evaluated by using the LOX/RNO, ORAC and TEAC methods. Very high AA was found, associated with a high fraction of freely-extractable phytochemicals expected to be readily absorbed in the small intestine and to exert systemic healthy effects. So, a possible beneficial effect of Lisosan G against non-alcoholic hepatic steatosis induced in mice by 90 days of hyperlipidic diet was studied. Feeding Lisosan G to mice with hepatic steatosis caused rapid reversion of liver disorder: just after 7 days the liver resulted free of steatosis, showing triglyceride content and histological properties similar to control group. Contrarily, the switch of hyperlipidic diet towards a standard diet did not rapidly reverse hepatic steatosis, with a recovery observed only after 30 days. Our results shed a first insight on the therapeutic potential of Lisosan G against the hepatic steatosis disorder in animal species.

Antioxidant-rich food supplement Lisosan G induces reversion of hepatic steatosis

F Denoth;M Ciardi;L Giorgetti;L Pucci;V Longo
2013

Abstract

Antioxidant activity (AA) of Lisosan G, a food supplement obtained from wheat grains, was evaluated by using the LOX/RNO, ORAC and TEAC methods. Very high AA was found, associated with a high fraction of freely-extractable phytochemicals expected to be readily absorbed in the small intestine and to exert systemic healthy effects. So, a possible beneficial effect of Lisosan G against non-alcoholic hepatic steatosis induced in mice by 90 days of hyperlipidic diet was studied. Feeding Lisosan G to mice with hepatic steatosis caused rapid reversion of liver disorder: just after 7 days the liver resulted free of steatosis, showing triglyceride content and histological properties similar to control group. Contrarily, the switch of hyperlipidic diet towards a standard diet did not rapidly reverse hepatic steatosis, with a recovery observed only after 30 days. Our results shed a first insight on the therapeutic potential of Lisosan G against the hepatic steatosis disorder in animal species.
2013
BIOLOGIA E BIOTECNOLOGIA AGRARIA
Antioxidant activity
hepatic steatosis
hyperlipidic diet
lisosan G
oxidative stress
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/173815
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