The study aimed to evaluate the transcriptional alterations of natriuretic peptides (NPs) and of its counter-regulatory system (ET-1 system) in the heart of Zucker rats (O, n=20), and lean controls (CO, n=20), subdivided in fasting and hyperglycemic, using Real Time-PCR. BNP and ANP mRNA resulted lower in O with respect to CO. A different regulation of the receptor NPR-A, NPR-B and NPR-C was showed in O. Both pre-proET-1 and ECE-1 were lower expressed in O (p=0.02) while ET-A and ET-B mRNA did not change in CO and O. Subdividing into fasting and hyperglycemic rats the behavior of each system remained quite similar. Our results suggest a reduced expression of both NPs and its counter-regulatory ET-1 system cardiac cells, the knowledge of this alteration can lead can lead to the progress of therapeutic strategies for the treatment of cardiometabolic syndrome.
Obesity modulates the transcriptional alterations of the natriuretic peptide and endothelin systems
Cabiati M;Caselli C;Prescimone T;Guzzardi M;Iozzo P;Giannessi D;Del Ry S
2013
Abstract
The study aimed to evaluate the transcriptional alterations of natriuretic peptides (NPs) and of its counter-regulatory system (ET-1 system) in the heart of Zucker rats (O, n=20), and lean controls (CO, n=20), subdivided in fasting and hyperglycemic, using Real Time-PCR. BNP and ANP mRNA resulted lower in O with respect to CO. A different regulation of the receptor NPR-A, NPR-B and NPR-C was showed in O. Both pre-proET-1 and ECE-1 were lower expressed in O (p=0.02) while ET-A and ET-B mRNA did not change in CO and O. Subdividing into fasting and hyperglycemic rats the behavior of each system remained quite similar. Our results suggest a reduced expression of both NPs and its counter-regulatory ET-1 system cardiac cells, the knowledge of this alteration can lead can lead to the progress of therapeutic strategies for the treatment of cardiometabolic syndrome.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
