Background: In end-stage heart failure (HF), the implantation of a left ventricular assist device (LVAD) is able to induce reverse remodeling. Cellular proteases, such as cathepsins, are involved in the progression of HF. The aim of this study was to evaluate the role of cathepsin system in HF patients supported by LVAD, in order to determine their involvement in cardiac remodeling.
Uncovering the cathepsin system in heart failure patients submitted to Left Ventricular Assist Device (LVAD) implantation
Caruso Raffaele;Prescimone Tommaso;Cabiati Manuela;Del Ry Silvia;Trivella Maria Giovanna;Giannessi Daniela;Caselli Chiara
2014
Abstract
Background: In end-stage heart failure (HF), the implantation of a left ventricular assist device (LVAD) is able to induce reverse remodeling. Cellular proteases, such as cathepsins, are involved in the progression of HF. The aim of this study was to evaluate the role of cathepsin system in HF patients supported by LVAD, in order to determine their involvement in cardiac remodeling.File in questo prodotto:
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