We reformulate the single-molecule analysis in an electron microscope in terms of a quantum-state discrimination problem, and discuss its implementation through electron-beam shaping. Our approach relies on the use of new electron-optical elements to efficiently extract the "which-molecule" information from the state of each electron. The optimal observables are formally derived, and subsequently implemented by suitably designed phase elements in a generalized orbital angular momentum sorter. As a representative example, we simulate the discrimination between model proteins and benchmark the performance of the sorter against that of the best known real-space approach.
Efficient molecule discrimination in electron microscopy through an optimized orbital angular momentum sorter
Troiani F;Rotunno E
;Frabboni S;Grillo V
2020
Abstract
We reformulate the single-molecule analysis in an electron microscope in terms of a quantum-state discrimination problem, and discuss its implementation through electron-beam shaping. Our approach relies on the use of new electron-optical elements to efficiently extract the "which-molecule" information from the state of each electron. The optimal observables are formally derived, and subsequently implemented by suitably designed phase elements in a generalized orbital angular momentum sorter. As a representative example, we simulate the discrimination between model proteins and benchmark the performance of the sorter against that of the best known real-space approach.File | Dimensione | Formato | |
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