Epidemiological evidences indicate that there is an inverse association between olive oil intake and bladder cancer risk and several data suggest that a key role to support these beneficial effects is played by its phenolic fraction. Bladder cancer is one of the most common cancers in Western countries. In particular, the transitional cell carcinoma histotype shows an aggressive behavior and the current therapies are ineffective. The anti-proliferative effects of an Extra Virgin Olive Oil phenolic Extract (EVOOE) has been investigated on RT112 and J82, two human bladder cancer cell lines employed as models of superficial and invasive bladder cancer, respectively
Extra Virgin Olive Oil Phenols induce authophagy and apoptosis in human bladder cancer cell lines depending on tumor progression
Carmela Spagnuolo;Maria Russo;Idolo Tedesco;Stefania Moccia;Carmen Cervellera;Gian Luigi Russo
2020
Abstract
Epidemiological evidences indicate that there is an inverse association between olive oil intake and bladder cancer risk and several data suggest that a key role to support these beneficial effects is played by its phenolic fraction. Bladder cancer is one of the most common cancers in Western countries. In particular, the transitional cell carcinoma histotype shows an aggressive behavior and the current therapies are ineffective. The anti-proliferative effects of an Extra Virgin Olive Oil phenolic Extract (EVOOE) has been investigated on RT112 and J82, two human bladder cancer cell lines employed as models of superficial and invasive bladder cancer, respectivelyI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.