Objectives Preventing age-related complications is a critical priority for health systems. Within the Age-It program, Spoke 8 aims to evaluate scalable, multicomponent, technology-assisted interventions to prevent frailty and mitigate functional and cognitive decline in older adults across different care settings. Methods Spoke 8 includes three clinical studies conducted in community, hospital, and long-term care settings, supported by cross-cutting work packages on digital infrastructure, technology development, and economic evaluation. The intervention model integrates physical, cognitive, nutritional, and psychosocial components, supported by digital tools, biomarkers of aging, and a centralized data platform. Results The project is expected to generate evidence on the effectiveness, feasibility, and cost-effectiveness of multidomain interventions implemented across diverse real-world settings, including community, hospital, and long-term care. Technology-assisted strategies - such as wearable sensors and digital cognitive tools - may enhance adherence and enable remote monitoring, while also supporting more personalized care delivery. The integration of artificial intelligence will facilitate the interpretation of complex clinical and biological data, improving risk stratification and the early identification of individuals most likely to benefit from targeted interventions. Together, these approaches may help reduce hospitalizations, delay functional decline, and promote aging in place. Discussion This initiative supports the transition toward more integrated and equitable care models for older adults. Through the implementation of scalable, person-centered interventions within routine services, the project offers policy-relevant strategies to address frailty and functional decline - contributing to the redesign of aging care in Italy and providing insights applicable across diverse health systems facing the challenges of population aging countries.
Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program
Noale, Marianna;Francioso, Luca;Ribino, Patrizia;Romeo, Zaira;Maggi, Stefania;Aloisi, Alessandra;Bulgari, Martina;Capone, Simonetta;Conti, Elisa;Di Napoli, Claudia;Goldin, Eris;Leone, Alessandro;Logrieco, Antonio;Macchia, Eleonora;Matteini, Paolo;Paragliola, Giovanni;Pirrelli, Vito;Sciurti, Elisa;Luca, Serino;Siciliano, Pietro;
2025
Abstract
Objectives Preventing age-related complications is a critical priority for health systems. Within the Age-It program, Spoke 8 aims to evaluate scalable, multicomponent, technology-assisted interventions to prevent frailty and mitigate functional and cognitive decline in older adults across different care settings. Methods Spoke 8 includes three clinical studies conducted in community, hospital, and long-term care settings, supported by cross-cutting work packages on digital infrastructure, technology development, and economic evaluation. The intervention model integrates physical, cognitive, nutritional, and psychosocial components, supported by digital tools, biomarkers of aging, and a centralized data platform. Results The project is expected to generate evidence on the effectiveness, feasibility, and cost-effectiveness of multidomain interventions implemented across diverse real-world settings, including community, hospital, and long-term care. Technology-assisted strategies - such as wearable sensors and digital cognitive tools - may enhance adherence and enable remote monitoring, while also supporting more personalized care delivery. The integration of artificial intelligence will facilitate the interpretation of complex clinical and biological data, improving risk stratification and the early identification of individuals most likely to benefit from targeted interventions. Together, these approaches may help reduce hospitalizations, delay functional decline, and promote aging in place. Discussion This initiative supports the transition toward more integrated and equitable care models for older adults. Through the implementation of scalable, person-centered interventions within routine services, the project offers policy-relevant strategies to address frailty and functional decline - contributing to the redesign of aging care in Italy and providing insights applicable across diverse health systems facing the challenges of population aging countries.| Campo DC | Valore | Lingua |
|---|---|---|
| dc.authority.ancejournal | JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES | en |
| dc.authority.orgunit | Istituto di Neuroscienze - IN - Sede Secondaria Padova | en |
| dc.authority.people | Okoye, Chukwuma | en |
| dc.authority.people | Cuffaro, Luca | en |
| dc.authority.people | Pozzi, Federico Emanuele | en |
| dc.authority.people | Ferrara, Maria Cristina | en |
| dc.authority.people | Noale, Marianna | en |
| dc.authority.people | Calciolari, Stefano | en |
| dc.authority.people | Chicco, Davide | en |
| dc.authority.people | Cincotti, Febo | en |
| dc.authority.people | Daini, Roberta | en |
| dc.authority.people | Finazzi, Alberto | en |
| dc.authority.people | Francioso, Luca | en |
| dc.authority.people | Gasparini, Francesca | en |
| dc.authority.people | Pagan, Eleonora | en |
| dc.authority.people | Ribino, Patrizia | en |
| dc.authority.people | Romeo, Zaira | en |
| dc.authority.people | Sala, Gessica | en |
| dc.authority.people | Solfrizzi, Vincenzo | en |
| dc.authority.people | Zambon, Antonella | en |
| dc.authority.people | Maggi, Stefania | en |
| dc.authority.people | Bellelli, Giuseppe | en |
| dc.authority.people | Ferrarese, Carlo | en |
| dc.authority.people | null, null | en |
| dc.authority.people | Airoldi, Cristna | en |
| dc.authority.people | Aloisi, Alessandra | en |
| dc.authority.people | Appollonio, Ildebrando | en |
| dc.authority.people | Bazzini, Chiara | en |
| dc.authority.people | Bochicchio, Mario Alessandro | en |
| dc.authority.people | Bologna, Matteo | en |
| dc.authority.people | Brattico, Elvira | en |
| dc.authority.people | Bruno, Giuseppe | en |
| dc.authority.people | Bulgari, Martina | en |
| dc.authority.people | Canevelli, Marco | en |
| dc.authority.people | Capone, Simonetta | en |
| dc.authority.people | Ceolin, Chiara | en |
| dc.authority.people | Chiaradonna, Ferdinando | en |
| dc.authority.people | Colamarino, Emma | en |
| dc.authority.people | Conti, Elisa | en |
| dc.authority.people | Corsonello, Andrea | en |
| dc.authority.people | Cortelessa, Gabriella | en |
| dc.authority.people | Crudele, Lucilla | en |
| dc.authority.people | Custodero, Carlo | en |
| dc.authority.people | De Luca, Annamaria | en |
| dc.authority.people | Delussi, Marianna | en |
| dc.authority.people | Di Napoli, Claudia | en |
| dc.authority.people | Dibello, Vittorio | en |
| dc.authority.people | Franchi, Matteo | en |
| dc.authority.people | Ganora, Diego | en |
| dc.authority.people | Gesualdo, Loreto | en |
| dc.authority.people | Goldin, Eris | en |
| dc.authority.people | Grossi, Alessandra | en |
| dc.authority.people | Isella, Valeria | en |
| dc.authority.people | Lenti, Roberta | en |
| dc.authority.people | Leone, Alessandro | en |
| dc.authority.people | Locati, Sandro | en |
| dc.authority.people | Logrieco, Antonio | en |
| dc.authority.people | Logroscino, Giancarlo | en |
| dc.authority.people | Macchia, Eleonora | en |
| dc.authority.people | Mantuano, Paola | en |
| dc.authority.people | Massimi, Azzurra | en |
| dc.authority.people | Matteini, Paolo | en |
| dc.authority.people | Messina, Giovanni | en |
| dc.authority.people | Moretti, Luca | en |
| dc.authority.people | Natalello, Antonino | en |
| dc.authority.people | Orlandi, Ivan | en |
| dc.authority.people | Paragliola, Giovanni | en |
| dc.authority.people | Paparella, Giulia | en |
| dc.authority.people | Pegoraro, Sara | en |
| dc.authority.people | Pirrelli, Vito | en |
| dc.authority.people | Quaranta, Nicola Antonio Adolfo | en |
| dc.authority.people | Riccardi, Giovanni | en |
| dc.authority.people | Romano, Daniele | en |
| dc.authority.people | Saibene, Aurora | en |
| dc.authority.people | Sala, Alessandro | en |
| dc.authority.people | Sciurti, Elisa | en |
| dc.authority.people | Luca, Serino | en |
| dc.authority.people | Siciliano, Pietro | en |
| dc.authority.people | Silanos, Francesco | en |
| dc.authority.people | Tamburrano, Alessio | en |
| dc.authority.people | Tosi, Giorgia | en |
| dc.authority.people | Tratsevich, Alina | en |
| dc.authority.people | Tremolizzo, Lucio | en |
| dc.authority.people | Villari, Paolo | en |
| dc.authority.people | Vezzoso, Alberto | en |
| dc.authority.people | Zoia, Chiara Paola | en |
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| dc.contributor.appartenenza | Dipartimento di Scienze del Sistema Terra e Tecnologie per l'Ambiente - DSSTTA | * |
| dc.contributor.appartenenza | Istituto di Bioimmagini e Sistemi Biologici Complessi (IBSBC) | * |
| dc.contributor.appartenenza | Istituto di Calcolo e Reti ad Alte Prestazioni - ICAR - Sede Secondaria Napoli | * |
| dc.contributor.appartenenza | Istituto di Calcolo e Reti ad Alte Prestazioni - ICAR - Sede Secondaria Palermo | * |
| dc.contributor.appartenenza | Istituto di Fisica Applicata - IFAC | * |
| dc.contributor.appartenenza | Istituto di Neuroscienze - IN - Sede Secondaria Padova | * |
| dc.contributor.appartenenza | Istituto di Scienze delle Produzioni Alimentari - ISPA | * |
| dc.contributor.appartenenza | Istituto di linguistica computazionale "Antonio Zampolli" - ILC | * |
| dc.contributor.appartenenza | Istituto per la Microelettronica e Microsistemi - IMM - Sede Secondaria Lecce | * |
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| dc.date.accessioned | 2026/01/26 11:34:58 | - |
| dc.date.available | 2026/01/26 11:34:58 | - |
| dc.date.firstsubmission | 2026/01/26 11:02:58 | * |
| dc.date.issued | 2025 | - |
| dc.date.submission | 2026/01/27 09:05:10 | * |
| dc.description.abstracteng | Objectives Preventing age-related complications is a critical priority for health systems. Within the Age-It program, Spoke 8 aims to evaluate scalable, multicomponent, technology-assisted interventions to prevent frailty and mitigate functional and cognitive decline in older adults across different care settings. Methods Spoke 8 includes three clinical studies conducted in community, hospital, and long-term care settings, supported by cross-cutting work packages on digital infrastructure, technology development, and economic evaluation. The intervention model integrates physical, cognitive, nutritional, and psychosocial components, supported by digital tools, biomarkers of aging, and a centralized data platform. Results The project is expected to generate evidence on the effectiveness, feasibility, and cost-effectiveness of multidomain interventions implemented across diverse real-world settings, including community, hospital, and long-term care. Technology-assisted strategies - such as wearable sensors and digital cognitive tools - may enhance adherence and enable remote monitoring, while also supporting more personalized care delivery. The integration of artificial intelligence will facilitate the interpretation of complex clinical and biological data, improving risk stratification and the early identification of individuals most likely to benefit from targeted interventions. Together, these approaches may help reduce hospitalizations, delay functional decline, and promote aging in place. Discussion This initiative supports the transition toward more integrated and equitable care models for older adults. Through the implementation of scalable, person-centered interventions within routine services, the project offers policy-relevant strategies to address frailty and functional decline - contributing to the redesign of aging care in Italy and providing insights applicable across diverse health systems facing the challenges of population aging countries. | - |
| dc.description.allpeople | Okoye, Chukwuma; Cuffaro, Luca; Pozzi, Federico Emanuele; Ferrara, Maria Cristina; Noale, Marianna; Calciolari, Stefano; Chicco, Davide; Cincotti, Febo; Daini, Roberta; Finazzi, Alberto; Francioso, Luca; Gasparini, Francesca; Pagan, Eleonora; Ribino, Patrizia; Romeo, Zaira; Sala, Gessica; Solfrizzi, Vincenzo; Zambon, Antonella; Maggi, Stefania; Bellelli, Giuseppe; Ferrarese, Carlo; Null, Null; Airoldi, Cristna; Aloisi, Alessandra; Appollonio, Ildebrando; Bazzini, Chiara; Bochicchio, Mario Alessandro; Bologna, Matteo; Brattico, Elvira; Bruno, Giuseppe; Bulgari, Martina; Canevelli, Marco; Capone, Simonetta; Ceolin, Chiara; Chiaradonna, Ferdinando; Colamarino, Emma; Conti, Elisa; Corsonello, Andrea; Cortelessa, Gabriella; Crudele, Lucilla; Custodero, Carlo; De Luca, Annamaria; Delussi, Marianna; Di Napoli, Claudia; Dibello, Vittorio; Franchi, Matteo; Ganora, Diego; Gesualdo, Loreto; Goldin, Eris; Grossi, Alessandra; Isella, Valeria; Lenti, Roberta; Leone, Alessandro; Locati, Sandro; Logrieco, Antonio; Logroscino, Giancarlo; Macchia, Eleonora; Mantuano, Paola; Massimi, Azzurra; Matteini, Paolo; Messina, Giovanni; Moretti, Luca; Natalello, Antonino; Orlandi, Ivan; Paragliola, Giovanni; Paparella, Giulia; Pegoraro, Sara; Pirrelli, Vito; Quaranta, Nicola Antonio Adolfo; Riccardi, Giovanni; Romano, Daniele; Saibene, Aurora; Sala, Alessandro; Sciurti, Elisa; Serino, Luca; Siciliano, Pietro; Silanos, Francesco; Tamburrano, Alessio; Tosi, Giorgia; Tratsevich, Alina; Tremolizzo, Lucio; Villari, Paolo; Vezzoso, Alberto; Zoia, Chiara Paola | - |
| dc.description.allpeopleoriginal | Okoye, Chukwuma; Cuffaro, Luca; Pozzi, Federico Emanuele; Ferrara, Maria Cristina; Noale, Marianna; Calciolari, Stefano; Chicco, Davide; Cincotti, Febo; Daini, Roberta; Finazzi, Alberto; Francioso, Luca; Gasparini, Francesca; Pagan, Eleonora; Ribino, Patrizia; Romeo, Zaira; Sala, Gessica; Solfrizzi, Vincenzo; Zambon, Antonella; Maggi, Stefania; Bellelli, Giuseppe; Ferrarese, Carlo; null, null; Airoldi, Cristna; Aloisi, Alessandra; Appollonio, Ildebrando; Bazzini, Chiara; Bochicchio, Mario Alessandro; Bologna, Matteo; Brattico, Elvira; Bruno, Giuseppe; Bulgari, Martina; Canevelli, Marco; Capone, Simonetta; Ceolin, Chiara; Chiaradonna, Ferdinando; Colamarino, Emma; Conti, Elisa; Corsonello, Andrea; Cortelessa, Gabriella; Crudele, Lucilla; Custodero, Carlo; De Luca, Annamaria; Delussi, Marianna; Di Napoli, Claudia; Dibello, Vittorio; Franchi, Matteo; Ganora, Diego; Gesualdo, Loreto; Goldin, Eris; Grossi, Alessandra; Isella, Valeria; Lenti, Roberta; Leone, Alessandro; Locati, Sandro; Logrieco, Antonio; Logroscino, Giancarlo; Macchia, Eleonora; Mantuano, Paola; Massimi, Azzurra; Matteini, Paolo; Messina, Giovanni; Moretti, Luca; Natalello, Antonino; Orlandi, Ivan; Paragliola, Giovanni; Paparella, Giulia; Pegoraro, Sara; Pirrelli, Vito; Quaranta, Nicola Antonio Adolfo; Riccardi, Giovanni; Romano, Daniele; Saibene, Aurora; Sala, Alessandro; Sciurti, Elisa; Luca, Serino; Siciliano, Pietro; Silanos, Francesco; Tamburrano, Alessio; Tosi, Giorgia; Tratsevich, Alina; Tremolizzo, Lucio; Villari, Paolo; Vezzoso, Alberto; Zoia, Chiara Paola | en |
| dc.description.fulltext | open | en |
| dc.description.numberofauthors | 84 | - |
| dc.identifier.doi | 10.1093/geronb/gbaf186 | en |
| dc.identifier.isi | WOS:001647169200001 | - |
| dc.identifier.scopus | 2-s2.0-105025524745 | en |
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| dc.identifier.uri | https://hdl.handle.net/20.500.14243/564586 | - |
| dc.language.iso | eng | en |
| dc.relation.issue | Supplement_2 | en |
| dc.relation.volume | 80 | en |
| dc.subject.keywordseng | Dementia | - |
| dc.subject.keywordseng | Frailty | - |
| dc.subject.keywordseng | Multidomain intervention | - |
| dc.subject.keywordseng | Prevention | - |
| dc.subject.keywordseng | Technology | - |
| dc.subject.singlekeyword | Dementia | * |
| dc.subject.singlekeyword | Frailty | * |
| dc.subject.singlekeyword | Multidomain intervention | * |
| dc.subject.singlekeyword | Prevention | * |
| dc.subject.singlekeyword | Technology | * |
| dc.title | Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program | en |
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| iris.isi.extTitle | Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program | - |
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| isi.authority.ancejournal | JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES###1079-5014 | * |
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| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | Consiglio Nazionale delle Ricerche (CNR) | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | IRCCS Santa Lucia | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | Consiglio Nazionale delle Ricerche (CNR) | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | Consiglio Nazionale delle Ricerche (CNR) | - |
| isi.contributor.affiliation | Consiglio Nazionale delle Ricerche (CNR) | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | Universita degli Studi di Bari Aldo Moro | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | Consiglio Nazionale delle Ricerche (CNR) | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.affiliation | University of Milano-Bicocca | - |
| isi.contributor.country | Italy | - |
| isi.contributor.country | Italy | - |
| isi.contributor.country | Italy | - |
| isi.contributor.country | Italy | - |
| isi.contributor.country | Italy | - |
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| isi.contributor.country | Italy | - |
| isi.contributor.country | Italy | - |
| isi.contributor.country | Italy | - |
| isi.contributor.country | Italy | - |
| isi.contributor.name | Chukwuma | - |
| isi.contributor.name | Luca | - |
| isi.contributor.name | Federico Emanuele | - |
| isi.contributor.name | Maria Cristina | - |
| isi.contributor.name | Marianna | - |
| isi.contributor.name | Stefano | - |
| isi.contributor.name | Davide | - |
| isi.contributor.name | Febo | - |
| isi.contributor.name | Roberta | - |
| isi.contributor.name | Alberto | - |
| isi.contributor.name | Luca | - |
| isi.contributor.name | Francesca | - |
| isi.contributor.name | Eleonora | - |
| isi.contributor.name | Patrizia | - |
| isi.contributor.name | Zaira | - |
| isi.contributor.name | Gessica | - |
| isi.contributor.name | Vincenzo | - |
| isi.contributor.name | Antonella | - |
| isi.contributor.name | Stefania | - |
| isi.contributor.name | Giuseppe | - |
| isi.contributor.name | Carlo | - |
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| isi.contributor.subaffiliation | Neurosci Inst | - |
| isi.contributor.subaffiliation | Dept Econ Management & Stat | - |
| isi.contributor.subaffiliation | Dept Informat Syst & Commun | - |
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| isi.contributor.subaffiliation | Sch Med & Surg | - |
| isi.contributor.subaffiliation | Sch Med & Surg | - |
| isi.contributor.surname | Okoye | - |
| isi.contributor.surname | Cuffaro | - |
| isi.contributor.surname | Pozzi | - |
| isi.contributor.surname | Ferrara | - |
| isi.contributor.surname | Noale | - |
| isi.contributor.surname | Calciolari | - |
| isi.contributor.surname | Chicco | - |
| isi.contributor.surname | Cincotti | - |
| isi.contributor.surname | Daini | - |
| isi.contributor.surname | Finazzi | - |
| isi.contributor.surname | Francioso | - |
| isi.contributor.surname | Gasparini | - |
| isi.contributor.surname | Pagan | - |
| isi.contributor.surname | Ribino | - |
| isi.contributor.surname | Romeo | - |
| isi.contributor.surname | Sala | - |
| isi.contributor.surname | Solfrizzi | - |
| isi.contributor.surname | Zambon | - |
| isi.contributor.surname | Maggi | - |
| isi.contributor.surname | Bellelli | - |
| isi.contributor.surname | Ferrarese | - |
| isi.date.issued | 2025 | * |
| isi.description.abstracteng | Objectives Preventing age-related complications is a critical priority for health systems. Within the Age-It program, Spoke 8 aims to evaluate scalable, multicomponent, technology-assisted interventions to prevent frailty and mitigate functional and cognitive decline in older adults across different care settings.Methods Spoke 8 includes three clinical studies conducted in community, hospital, and long-term care settings, supported by cross-cutting work packages on digital infrastructure, technology development, and economic evaluation. The intervention model integrates physical, cognitive, nutritional, and psychosocial components, supported by digital tools, biomarkers of aging, and a centralized data platform.Results The project is expected to generate evidence on the effectiveness, feasibility, and cost-effectiveness of multidomain interventions implemented across diverse real-world settings, including community, hospital, and long-term care. Technology-assisted strategies-such as wearable sensors and digital cognitive tools-may enhance adherence and enable remote monitoring, while also supporting more personalized care delivery. The integration of artificial intelligence will facilitate the interpretation of complex clinical and biological data, improving risk stratification and the early identification of individuals most likely to benefit from targeted interventions. Together, these approaches may help reduce hospitalizations, delay functional decline, and promote aging in place.Discussion This initiative supports the transition toward more integrated and equitable care models for older adults. Through the implementation of scalable, person-centered interventions within routine services, the project offers policy-relevant strategies to address frailty and functional decline-contributing to the redesign of aging care in Italy and providing insights applicable across diverse health systems facing the challenges of population aging countries. | * |
| isi.description.allpeopleoriginal | Okoye, C; Cuffaro, L; Pozzi, FE; Ferrara, MC; Noale, M; Calciolari, S; Chicco, D; Cincotti, F; Daini, R; Finazzi, A; Francioso, L; Gasparini, F; Pagan, E; Ribino, P; Romeo, Z; Sala, G; Solfrizzi, V; Zambon, A; Maggi, S; Bellelli, G; Ferrarese, C; | * |
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| isi.document.type | Article | * |
| isi.document.types | Article | * |
| isi.identifier.doi | 10.1093/geronb/gbaf186 | * |
| isi.identifier.eissn | 1758-5368 | * |
| isi.identifier.isi | WOS:001647169200001 | * |
| isi.journal.journaltitle | JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES | * |
| isi.journal.journaltitleabbrev | J GERONTOL B-PSYCHOL | * |
| isi.language.original | English | * |
| isi.publisher.place | JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA | * |
| isi.relation.firstpage | S180 | * |
| isi.relation.lastpage | S188 | * |
| isi.relation.volume | 80 | * |
| isi.title | Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program | * |
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| scopus.date.issued | 2025 | * |
| scopus.description.abstracteng | Objectives Preventing age-related complications is a critical priority for health systems. Within the Age-It program, Spoke 8 aims to evaluate scalable, multicomponent, technology-assisted interventions to prevent frailty and mitigate functional and cognitive decline in older adults across different care settings. Methods Spoke 8 includes three clinical studies conducted in community, hospital, and long-term care settings, supported by cross-cutting work packages on digital infrastructure, technology development, and economic evaluation. The intervention model integrates physical, cognitive, nutritional, and psychosocial components, supported by digital tools, biomarkers of aging, and a centralized data platform. Results The project is expected to generate evidence on the effectiveness, feasibility, and cost-effectiveness of multidomain interventions implemented across diverse real-world settings, including community, hospital, and long-term care. Technology-assisted strategies - such as wearable sensors and digital cognitive tools - may enhance adherence and enable remote monitoring, while also supporting more personalized care delivery. The integration of artificial intelligence will facilitate the interpretation of complex clinical and biological data, improving risk stratification and the early identification of individuals most likely to benefit from targeted interventions. Together, these approaches may help reduce hospitalizations, delay functional decline, and promote aging in place. Discussion This initiative supports the transition toward more integrated and equitable care models for older adults. Through the implementation of scalable, person-centered interventions within routine services, the project offers policy-relevant strategies to address frailty and functional decline - contributing to the redesign of aging care in Italy and providing insights applicable across diverse health systems facing the challenges of population aging countries. | * |
| scopus.description.allpeopleoriginal | Okoye C.; Cuffaro L.; Pozzi F.E.; Ferrara M.C.; Noale M.; Calciolari S.; Chicco D.; Cincotti F.; Daini R.; Finazzi A.; Francioso L.; Gasparini F.; Pagan E.; Ribino P.; Romeo Z.; Sala G.; Solfrizzi V.; Zambon A.; Maggi S.; Bellelli G.; Ferrarese C.; Airoldi C.; Aloisi A.; Appollonio I.; Bazzini C.; Bochicchio M.A.; Bologna M.; Brattico E.; Bruno G.; Bulgari M.; Canevelli M.; Capone S.; Ceolin C.; Chiaradonna F.; Colamarino E.; Conti E.; Corsonello A.; Cortelessa G.; Crudele L.; Custodero C.; De Luca A.; Delussi M.; Di Napoli C.; Dibello V.; Franchi M.; Ganora D.; Gesualdo L.; Goldin E.; Grossi A.; Isella V.; Lenti R.; Leone A.; Locati S.; Logrieco A.; Logroscino G.; Macchia E.; Mantuano P.; Massimi A.; Matteini P.; Messina G.; Moretti L.; Natalello A.; Orlandi I.; Paragliola G.; Paparella G.; Pegoraro S.; Pirrelli V.; Quaranta N.A.A.; Riccardi G.; Romano D.; Saibene A.; Sala A.; Sciurti E.; Luca S.; Siciliano P.; Silanos F.; Tamburrano A.; Tosi G.; Tratsevich A.; Tremolizzo L.; Villari P.; Vezzoso A.; Zoia C.P. | * |
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| scopus.funding.funders | 501100002954 - Università degli Studi di Milano-Bicocca; 501100004271 - Sapienza Università di Roma; 501100003500 - Università degli Studi di Padova; 501100005362 - Universita degli Studi di Bari Aldo Moro; | * |
| scopus.identifier.doi | 10.1093/geronb/gbaf186 | * |
| scopus.identifier.eissn | 1758-5368 | * |
| scopus.identifier.pmid | 41442763 | * |
| scopus.identifier.pui | 2042481596 | * |
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| scopus.publisher.name | Gerontological Society of America | * |
| scopus.relation.firstpage | S180 | * |
| scopus.relation.lastpage | S188 | * |
| scopus.relation.volume | 80 | * |
| scopus.subject.keywords | Dementia; Frailty; Multidomain intervention; Prevention; Technology; | * |
| scopus.title | Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program | * |
| scopus.titleeng | Multicomponent interventions and technologies to reduce the burden of frailty, functional, and cognitive decline: insights from the Age-It Research Program | * |
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