Alterations in the leucine-rich kinase 2 gene (LRRK2; MIM *609007) have been shown to cause an autosomal dominant form of PARK8-linked parkinsonism (1, 2). Within this gene, the G6055A mutation (exon 41; Gly2019Ser) represents the most common mutation described to date both in familial and in sporadic forms of Parkinsons disease (PD).
LRRK2 G6055A mutation in Italian patients with familial or sporadic Parkinson's disease
D Civitelli;P Tarantino;G Nicoletti;F Annesi;EV De Marco;P Spadafora;P Pugliese;G Annesi;A Quattrone
2007
Abstract
Alterations in the leucine-rich kinase 2 gene (LRRK2; MIM *609007) have been shown to cause an autosomal dominant form of PARK8-linked parkinsonism (1, 2). Within this gene, the G6055A mutation (exon 41; Gly2019Ser) represents the most common mutation described to date both in familial and in sporadic forms of Parkinsons disease (PD).File in questo prodotto:
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Descrizione: LRRK2 G6055A mutation in Italian patients with familial or sporadic Parkinson’s disease
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