CNR Institutional Research Information System

CRESPAN, EMMANUELE
 Distribuzione geografica
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Continente #
AS - Asia 1.764
NA - Nord America 1.108
EU - Europa 347
SA - Sud America 280
AF - Africa 30
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 2
Totale 3.535
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Nazione #
US - Stati Uniti d'America 1.079
SG - Singapore 713
CN - Cina 480
BR - Brasile 232
VN - Vietnam 178
HK - Hong Kong 146
KR - Corea 96
FR - Francia 87
IT - Italia 78
NL - Olanda 64
IN - India 29
DE - Germania 25
JP - Giappone 23
FI - Finlandia 21
AR - Argentina 16
GB - Regno Unito 16
IL - Israele 16
BD - Bangladesh 13
MX - Messico 12
ZA - Sudafrica 12
CA - Canada 11
ID - Indonesia 9
IQ - Iraq 9
TR - Turchia 9
UZ - Uzbekistan 9
PL - Polonia 8
EC - Ecuador 7
ES - Italia 7
PK - Pakistan 6
DZ - Algeria 5
LT - Lituania 5
PE - Perù 5
PY - Paraguay 5
SA - Arabia Saudita 5
TW - Taiwan 5
UA - Ucraina 5
UY - Uruguay 5
CL - Cile 4
AE - Emirati Arabi Uniti 3
AL - Albania 3
AT - Austria 3
CO - Colombia 3
KE - Kenya 3
MA - Marocco 3
RS - Serbia 3
RU - Federazione Russa 3
AU - Australia 2
AZ - Azerbaigian 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
EG - Egitto 2
GA - Gabon 2
GR - Grecia 2
IE - Irlanda 2
JO - Giordania 2
MY - Malesia 2
PT - Portogallo 2
SK - Slovacchia (Repubblica Slovacca) 2
VE - Venezuela 2
AM - Armenia 1
BG - Bulgaria 1
BO - Bolivia 1
BY - Bielorussia 1
CR - Costa Rica 1
CW - ???statistics.table.value.countryCode.CW??? 1
EE - Estonia 1
GE - Georgia 1
GG - Guernsey 1
GN - Guinea 1
HN - Honduras 1
KZ - Kazakistan 1
LB - Libano 1
ME - Montenegro 1
MK - Macedonia 1
MT - Malta 1
NZ - Nuova Zelanda 1
OM - Oman 1
PA - Panama 1
PF - Polinesia Francese 1
PH - Filippine 1
RO - Romania 1
SE - Svezia 1
SN - Senegal 1
SV - El Salvador 1
SY - Repubblica araba siriana 1
TG - Togo 1
TH - Thailandia 1
TL - Timor Orientale 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 3.535
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Città #
Santa Clara 610
Singapore 413
Hefei 242
Hong Kong 143
San Jose 113
Beijing 94
Seoul 94
Lauterbourg 77
Ashburn 69
Ho Chi Minh City 66
Dallas 47
Hanoi 41
Pavia 36
São Paulo 22
Los Angeles 21
Minamishinagawa 15
New York 15
Bengaluru 14
Helsinki 12
Salt Lake City 12
Buffalo 11
Haiphong 11
Frankfurt am Main 10
Lappeenranta 8
Tashkent 8
Tokyo 8
Belo Horizonte 7
Porto Alegre 7
Da Nang 6
Düsseldorf 6
Rio de Janeiro 6
Fortaleza 5
Guangzhou 5
Lima 5
Milan 5
Montevideo 5
Rome 5
Warsaw 5
Dhaka 4
Johannesburg 4
Piscataway 4
Portsmouth 4
Quito 4
Shanghai 4
Asunción 3
Baghdad 3
Belgrade 3
Betim 3
Biên Hòa 3
Brasília 3
Bắc Ninh 3
Canoas 3
Council Bluffs 3
Curitiba 3
Elk Grove Village 3
Falkenstein 3
Goiânia 3
Guarulhos 3
Houston 3
Istanbul 3
Kyiv 3
Manaus 3
Mexico City 3
Mumbai 3
Munich 3
Newark 3
Nha Trang 3
Ninh Bình 3
Orem 3
Phủ Lý 3
Quận Bốn 3
São José do Rio Preto 3
Thái Nguyên 3
Vienna 3
Amman 2
Atlanta 2
Baku 2
Barakaldo 2
Boston 2
Bratislava 2
Brooklyn 2
Bình Dương 2
Cachoeiro de Itapemirim 2
Cairo 2
Caxias do Sul 2
Chang-hua 2
Chicago 2
Denver 2
Dourados 2
Dublin 2
Esteio 2
Flint 2
Franca 2
Fremont 2
Genoa 2
Hangzhou 2
Ibiporã 2
Islamabad 2
Ituiutaba 2
Jundiaí 2
Totale 2.445
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Nome #
Human DNA Polymerase beta, but Not lambda, Can Bypass a 2-Deoxyribonolactone Lesion Together with Proliferating Cell Nuclear Antigen 82
The power of enzyme kinetics in the drug development process 78
Slow-, Tight-Binding HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors Highly Active against Drug-Resistant Mutants. 75
Selective binding and redox-activity on parallel g-quadruplexes by pegylated naphthalene diimide-copper complexes 75
Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops 75
Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents 71
Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure-Activity Relationships, and Docking Studies (Part 2). 67
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. 67
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the 66
Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line 64
New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: Discovery, characterization, and crystal structure in complex with the target 64
Truncating Variants in RFC1 in Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome 64
p15PAF binding to PCNA modulates the DNA sliding surface 63
Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis 63
Ribonucleotide incorporation by human DNA polymerase eta impacts translesion synthesis and RNase H2 activity 61
A role for human dna polymerase λ in alternative lengthening of telomeres 59
Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor 58
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains 57
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2 56
Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. 55
Synthesis and Biological Investigation of Peptidomimetic SARS-CoV-2 Main Protease (Mpro) Inhibitors Bearing Quinoline-based Heterocycles at P3. 55
Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4- d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme 53
Novel pyrazolo[3,4-d]pyrimidines as dual Src/Bcr-Abl kinase inhibitors: Synthesis and biological evaluation for chronic myeloid leukemia treatment 52
Applying molecular hybridization to design a new class of pyrazolo[3,4-d]pyrimidines as Src inhibitors active in hepatocellular carcinoma 51
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 50
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIII beta) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses 50
DNA Polymerases lambda and beta: The Double-Edged Swords of DNA Repair. 47
High flexibility of rnaseh2 catalytic activity with respect to non-canonical dna structures 47
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect 46
8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. 44
A novel G-Quadruplex structure within Apolipoprotein E promoter: a new promising target in cancer and dementia fight? 44
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections 43
Effect of alpha-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3H)-ones 43
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma 43
How to win the HIV-1 drug resistance hurdle race: Running faster or jumping higher? 42
Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors 41
Bithiazole inhibitors of PI4KB show broad-spectrum antiviral activity against different viral families 40
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 38
Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents. 38
Overcoming the Drug Resistance Problem with Second-Generation Tyrosine Kinase Inhibitors: From Enzymology to Structural Models. 38
Oxidative DNA Damage Bypass in Arabidopsis thaliana Requires DNA Polymerase {lambda} and Proliferating Cell Nuclear Antigen 2. 38
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines 34
Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases lamda and beta on normal and repetitive DNA sequences 34
Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors 33
New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors 33
The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides. 33
New in silico and conventional in vitro approaches to advance HIV drug discovery and design 33
A new proofreading mechanism for lesion bypass by DNA polymerase-lambda 32
Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study. 32
Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes 32
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant 31
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. 31
The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: Implications for drug design 30
Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors. 30
Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. 30
DNA polymerases and mutagenesis in human cancers. 29
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. 29
DNA polymerase delta-interacting protein 2 is a processivity factor for DNA polymerase lambda during 8-oxo-7,8-dihydroguanine bypass. 29
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 29
Roles of the human proteins PCNA, RP-A and Fen-1 in avoiding functional redundance between human DNA polymerases b and l in genomic stability safeguarding. 29
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 28
Pyrazolo[3,4-d]pyrimidine prodrugs: Strategic optimization of the aqueous solubility of dual Src/Abl inhibitors 28
3D QSAR Models Built on Structure-Based Alignments of Abl Tyrosine Kinase Inhibitors. 27
Expansion of CAG triplet repeats by human DNA polymerases lambda and beta in vitro, is regulated by flap endonuclease 1 and DNA ligase 1 27
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family 27
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action. 27
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. 27
Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. 26
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. 26
The goods and bads of DNA polymerases ? and ? actions on CAG repeats and telomeric DNA sequences 26
Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach + 26
The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and flap endonuclease 1. 26
Molecular docking, design, synthesis and biological evaluation of novel 2,3-aryl-thiazolidin-4-ones as potent NNRTIs 25
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant. 25
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms. 25
Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana 25
DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions 25
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. 24
Impact of ribonucleotide incorporation by DNA polymerases beta and lambda on oxidative base excision repair. 24
Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide. 24
Exploring the chemical space around the privileged pyrazolo[3,4-d] pyrimidine scaffold: Toward novel allosteric inhibitors of T315I-mutated Abl 24
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma 24
Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana 23
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda. 23
N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the Synthesis of Inhibitors of Bcr-Abl. 23
The Incorporation of Ribonucleotides Induces Structural and Conformational Changes in DNA 22
Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti-HIV Agents 22
Tyrosine kinases as essential cellular cofactors and potential therapeutic targets for human immunodeficiency virus infection 22
DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions 21
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. 20
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 20
Developing Type II F508del-CFTR correctors with a protective effect against respiratory viruses 18
Totale 3.636
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Categoria #
all - tutte 11.366
article - articoli 10.829
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 22.195
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2023/202418 0 0 0 0 0 0 0 0 18 0 0 0
2024/20251.646 1 5 84 43 580 116 23 50 62 85 317 280
2025/20261.972 151 278 230 322 332 65 260 91 59 129 55 0
Totale 3.636