CNR Institutional Research Information System

CRESPAN, EMMANUELE
 Distribuzione geografica
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Continente #
AS - Asia 1.840
NA - Nord America 1.476
EU - Europa 407
SA - Sud America 310
Continente sconosciuto - Info sul continente non disponibili 103
AF - Africa 31
OC - Oceania 4
Totale 4.171
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Nazione #
US - Stati Uniti d'America 1.418
SG - Singapore 714
CN - Cina 482
BR - Brasile 241
VN - Vietnam 184
HK - Hong Kong 147
IT - Italia 125
KR - Corea 96
FR - Francia 89
BD - Bangladesh 69
NL - Olanda 65
IN - India 29
DE - Germania 26
JP - Giappone 23
FI - Finlandia 21
CA - Canada 20
GB - Regno Unito 19
AR - Argentina 18
IL - Israele 16
CO - Colombia 13
MX - Messico 13
ZA - Sudafrica 12
EC - Ecuador 11
ID - Indonesia 11
IQ - Iraq 9
TR - Turchia 9
UZ - Uzbekistan 9
PL - Polonia 8
UA - Ucraina 8
ES - Italia 7
VE - Venezuela 7
CR - Costa Rica 6
MY - Malesia 6
PK - Pakistan 6
DZ - Algeria 5
LT - Lituania 5
PE - Perù 5
PY - Paraguay 5
SA - Arabia Saudita 5
TW - Taiwan 5
UY - Uruguay 5
CL - Cile 4
HN - Honduras 4
JM - Giamaica 4
PH - Filippine 4
RS - Serbia 4
AE - Emirati Arabi Uniti 3
AL - Albania 3
AT - Austria 3
DK - Danimarca 3
KE - Kenya 3
MA - Marocco 3
RU - Federazione Russa 3
AU - Australia 2
AZ - Azerbaigian 2
BG - Bulgaria 2
DO - Repubblica Dominicana 2
EG - Egitto 2
GA - Gabon 2
GR - Grecia 2
IE - Irlanda 2
JO - Giordania 2
NI - Nicaragua 2
PT - Portogallo 2
SK - Slovacchia (Repubblica Slovacca) 2
SV - El Salvador 2
TH - Thailandia 2
TT - Trinidad e Tobago 2
AM - Armenia 1
BO - Bolivia 1
BY - Bielorussia 1
CW - ???statistics.table.value.countryCode.CW??? 1
EE - Estonia 1
GE - Georgia 1
GG - Guernsey 1
GN - Guinea 1
GT - Guatemala 1
KZ - Kazakistan 1
LB - Libano 1
ME - Montenegro 1
MK - Macedonia 1
MT - Malta 1
NZ - Nuova Zelanda 1
OM - Oman 1
PA - Panama 1
PF - Polinesia Francese 1
RO - Romania 1
SC - Seychelles 1
SE - Svezia 1
SN - Senegal 1
SY - Repubblica araba siriana 1
TG - Togo 1
TL - Timor Orientale 1
VC - Saint Vincent e Grenadine 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 4.070
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Città #
Santa Clara 612
Singapore 414
Hefei 242
Hong Kong 144
San Jose 144
Ashburn 104
Beijing 94
Seoul 94
Lauterbourg 77
Ho Chi Minh City 68
Dallas 48
Hanoi 43
Pavia 36
Los Angeles 26
São Paulo 22
New York 20
Minamishinagawa 15
Bengaluru 14
Buffalo 12
Helsinki 12
Salt Lake City 12
Chicago 11
Haiphong 11
Frankfurt am Main 10
Council Bluffs 9
Rome 9
Lappeenranta 8
Tashkent 8
Tokyo 8
Atlanta 7
Belo Horizonte 7
Milan 7
Porto Alegre 7
Da Nang 6
Düsseldorf 6
Rio de Janeiro 6
San José 6
Brooklyn 5
Fortaleza 5
Guangzhou 5
Kingston 5
Lima 5
Montevideo 5
Newark 5
Philadelphia 5
The Bronx 5
Warsaw 5
Belgrade 4
Boardman 4
Bogotá 4
Boston 4
Detroit 4
Dhaka 4
Houston 4
Johannesburg 4
Kuala Lumpur 4
Naples 4
Piscataway 4
Portsmouth 4
Quito 4
Seattle 4
Shanghai 4
Asunción 3
Baghdad 3
Betim 3
Biên Hòa 3
Brasília 3
Bắc Ninh 3
Calgary 3
Canoas 3
Curitiba 3
Elk Grove Village 3
Falkenstein 3
Goiânia 3
Greensboro 3
Guarulhos 3
Guayaquil 3
Istanbul 3
Kyiv 3
Louisville 3
Manaus 3
Mexico City 3
Miami 3
Milwaukee 3
Montreal 3
Mumbai 3
Munich 3
Nha Trang 3
Ninh Bình 3
Orem 3
Orlando 3
Phoenix 3
Phủ Lý 3
Poltava 3
Queens 3
Quận Bốn 3
São José do Rio Preto 3
Thanh Hóa 3
Thái Nguyên 3
Vienna 3
Totale 2.603
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Nome #
Synthesis and Biological Investigation of Peptidomimetic SARS-CoV-2 Main Protease (Mpro) Inhibitors Bearing Quinoline-based Heterocycles at P3. 124
Human DNA Polymerase beta, but Not lambda, Can Bypass a 2-Deoxyribonolactone Lesion Together with Proliferating Cell Nuclear Antigen 86
The power of enzyme kinetics in the drug development process 81
Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops 81
Selective binding and redox-activity on parallel g-quadruplexes by pegylated naphthalene diimide-copper complexes 80
Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents 79
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the 79
Slow-, Tight-Binding HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitors Highly Active against Drug-Resistant Mutants. 79
New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: Discovery, characterization, and crystal structure in complex with the target 73
Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis 73
Truncating Variants in RFC1 in Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome 72
Arylthiopyrrole (AThP) Derivatives as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis, Structure-Activity Relationships, and Docking Studies (Part 2). 71
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide. 68
Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line 68
Novel pyrazolo[3,4-d]pyrimidines as dual Src/Bcr-Abl kinase inhibitors: Synthesis and biological evaluation for chronic myeloid leukemia treatment 67
Ribonucleotide incorporation by human DNA polymerase eta impacts translesion synthesis and RNase H2 activity 66
p15PAF binding to PCNA modulates the DNA sliding surface 65
Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor 64
Error-free bypass of 2-hydroxyadenine by human DNA polymerase lambda with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts. 63
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains 63
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2 63
A role for human dna polymerase λ in alternative lengthening of telomeres 62
Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4- d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme 60
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIII beta) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses 59
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors 57
Applying molecular hybridization to design a new class of pyrazolo[3,4-d]pyrimidines as Src inhibitors active in hepatocellular carcinoma 57
A novel G-Quadruplex structure within Apolipoprotein E promoter: a new promising target in cancer and dementia fight? 52
DNA Polymerases lambda and beta: The Double-Edged Swords of DNA Repair. 51
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect 51
High flexibility of rnaseh2 catalytic activity with respect to non-canonical dna structures 51
8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. 49
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma 49
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections 48
Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors 48
Bithiazole inhibitors of PI4KB show broad-spectrum antiviral activity against different viral families 47
How to win the HIV-1 drug resistance hurdle race: Running faster or jumping higher? 47
Effect of alpha-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3H)-ones 45
Overcoming the Drug Resistance Problem with Second-Generation Tyrosine Kinase Inhibitors: From Enzymology to Structural Models. 44
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 41
Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents. 41
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. 41
Oxidative DNA Damage Bypass in Arabidopsis thaliana Requires DNA Polymerase {lambda} and Proliferating Cell Nuclear Antigen 2. 41
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines 39
The balance between the rates of incorporation and pyrophosphorolytic removal influences the HIV-1 reverse transcriptase bypass of an abasic site with deoxy-, dideoxy-, and ribonucleotides. 39
The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: Implications for drug design 38
Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases lamda and beta on normal and repetitive DNA sequences 38
New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors 37
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds. 37
Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors 36
Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds 36
Pyrazolo[3,4-d]pyrimidine prodrugs: Strategic optimization of the aqueous solubility of dual Src/Abl inhibitors 36
Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes 36
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment 36
Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study. 35
New in silico and conventional in vitro approaches to advance HIV drug discovery and design 35
A combination strategy to inhibit Pim-1: synergism between noncompetitive and ATP-competitive inhibitors. 35
Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines. 35
Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. 34
Crystal Structure of HIV-1 Reverse Transcriptase Bound to a Non-Nucleoside Inhibitor with a Novel Mechanism of Action. 34
A new proofreading mechanism for lesion bypass by DNA polymerase-lambda 33
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant 33
The goods and bads of DNA polymerases ? and ? actions on CAG repeats and telomeric DNA sequences 33
Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors. 33
Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. 33
DNA polymerases and mutagenesis in human cancers. 32
Expansion of CAG triplet repeats by human DNA polymerases lambda and beta in vitro, is regulated by flap endonuclease 1 and DNA ligase 1 31
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms. 31
Roles of the human proteins PCNA, RP-A and Fen-1 in avoiding functional redundance between human DNA polymerases b and l in genomic stability safeguarding. 31
DNA polymerase delta-interacting protein 2 is a processivity factor for DNA polymerase lambda during 8-oxo-7,8-dihydroguanine bypass. 30
Impact of ribonucleotide incorporation by DNA polymerases beta and lambda on oxidative base excision repair. 30
Exploring the chemical space around the privileged pyrazolo[3,4-d] pyrimidine scaffold: Toward novel allosteric inhibitors of T315I-mutated Abl 30
N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the Synthesis of Inhibitors of Bcr-Abl. 30
Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana 30
The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and flap endonuclease 1. 30
3D QSAR Models Built on Structure-Based Alignments of Abl Tyrosine Kinase Inhibitors. 29
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant. 29
Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach + 29
Biochemical Approach of PCNA1 and PCNA2 proteins interaction with DNA pol lambda of Arabidopsis thaliana 28
Molecular docking, design, synthesis and biological evaluation of novel 2,3-aryl-thiazolidin-4-ones as potent NNRTIs 28
Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family 28
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma 28
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. 27
The Incorporation of Ribonucleotides Induces Structural and Conformational Changes in DNA 27
Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti-HIV Agents 27
DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions 27
Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carboxamide. 26
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda. 26
DNA polymerase lambda specifically bridges and extends DNA ends containing microhomoloy regions 26
Tyrosine kinases as essential cellular cofactors and potential therapeutic targets for human immunodeficiency virus infection 25
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases 24
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. 23
Developing Type II F508del-CFTR correctors with a protective effect against respiratory viruses 22
Totale 4.171
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Categoria #
all - tutte 14.054
article - articoli 13.395
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.449
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2023/202418 0 0 0 0 0 0 0 0 18 0 0 0
2024/20251.646 1 5 84 43 580 116 23 50 62 85 317 280
2025/20262.082 151 278 230 322 332 65 260 91 59 129 59 106
2026/2027425 98 111 216 0 0 0 0 0 0 0 0 0
Totale 4.171